| Reaction Details |
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 | Report a problem with these data |
| Target | fMet-Leu-Phe receptor |
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| Ligand | BDBM50559822 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2070441 (CHEMBL4725975) |
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| EC50 | 190±n/a nM |
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| Citation |  Asahina, Y; Wurtz, NR; Arakawa, K; Carson, N; Fujii, K; Fukuchi, K; Garcia, R; Hsu, MY; Ishiyama, J; Ito, B; Kick, E; Lupisella, J; Matsushima, S; Ohata, K; Ostrowski, J; Saito, Y; Tsuda, K; Villarreal, F; Yamada, H; Yamaoka, T; Wexler, R; Gordon, D; Kohno, Y Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure. J Med Chem63:9003-9019 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| fMet-Leu-Phe receptor |
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| Name: | fMet-Leu-Phe receptor |
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| Synonyms: | FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38456.14 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_4503779 |
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| Residue: | 350 |
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| Sequence: | METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVT
TISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIA
LDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNF
SPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPL
RVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPML
YVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
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| BDBM50559822 |
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| n/a |
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| Name | BDBM50559822 |
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| Synonyms: | CHEMBL4753713 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16F2N4O3 |
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| Mol. Mass. | 362.3307 |
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| SMILES | COc1cnc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 |r| |
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| Structure | 
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