| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Toll-like receptor 9 |
|---|
| Ligand | BDBM50560348 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2071951 (CHEMBL4727485) |
|---|
| IC50 | 1200±n/a nM |
|---|
| Citation |  Alper, PB; Deane, J; Betschart, C; Buffet, D; Collignon Zipfel, G; Gordon, P; Hampton, J; Hawtin, S; Ibanez, M; Jiang, T; Junt, T; Knoepfel, T; Liu, B; Maginnis, J; McKeever, U; Michellys, PY; Mutnick, D; Nayak, B; Niwa, S; Richmond, W; Rush, JS; Syka, P; Zhang, Y; Zhu, X Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Toll-like receptor 9 |
|---|
| Name: | Toll-like receptor 9 |
|---|
| Synonyms: | CD_antigen=CD289 | TLR9_MOUSE | Tlr9 | Toll-like receptor 9 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 116449.39 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_101453 |
|---|
| Residue: | 1032 |
|---|
| Sequence: | MVLRRRTLHPLSLLVQAAVLAETLALGTLPAFLPCELKPHGLVDCNWLFLKSVPRFSAAA
SCSNITRLSLISNRIHHLHNSDFVHLSNLRQLNLKWNCPPTGLSPLHFSCHMTIEPRTFL
AMRTLEELNLSYNGITTVPRLPSSLVNLSLSHTNILVLDANSLAGLYSLRVLFMDGNCYY
KNPCTGAVKVTPGALLGLSNLTHLSLKYNNLTKVPRQLPPSLEYLLVSYNLIVKLGPEDL
ANLTSLRVLDVGGNCRRCDHAPNPCIECGQKSLHLHPETFHHLSHLEGLVLKDSSLHTLN
SSWFQGLVNLSVLDLSENFLYESITHTNAFQNLTRLRKLNLSFNYRKKVSFARLHLASSF
KNLVSLQELNMNGIFFRLLNKYTLRWLADLPKLHTLHLQMNFINQAQLSIFGTFRALRFV
DLSDNRISGPSTLSEATPEEADDAEQEELLSADPHPAPLSTPASKNFMDRCKNFKFTMDL
SRNNLVTIKPEMFVNLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWK
SFSELPQLQALDLSYNSQPFSMKGIGHNFSFVTHLSMLQSLSLAHNDIHTRVSSHLNSNS
VRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNLDNLPKSLKLLS
LRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTNGTLPNGTLLQKLDVSSNSIVSVVPA
FFALAVELKEVNLSHNILKTVDRSWFGPIVMNLTVLDVRSNPLHCACGAAFVDLLLEVQT
KVPGLANGVKCGSPGQLQGRSIFAQDLRLCLDEVLSWDCFGLSLLAVAVGMVVPILHHLC
GWDVWYCFHLCLAWLPLLARSRRSAQTLPYDAFVVFDKAQSAVADWVYNELRVRLEERRG
RRALRLCLEDRDWLPGQTLFENLWASIYGSRKTLFVLAHTDRVSGLLRTSFLLAQQRLLE
DRKDVVVLVILRPDAHRSRYVRLRQRLCRQSVLFWPQQPNGQGGFWAQLSTALTRDNRHF
YNQNFCRGPTAE
|
|
|
|---|
| BDBM50560348 |
|---|
| n/a |
|---|
| Name | BDBM50560348 |
|---|
| Synonyms: | CHEMBL4796453 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H23FN6O |
|---|
| Mol. Mass. | 382.4346 |
|---|
| SMILES | [H][C@]12CC[C@]([H])(CC(COc3ccc(cc3F)-c3nn(C)c4nc(N)ncc34)C1)N2 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
