| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 9 |
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| Ligand | BDBM50560353 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2071951 (CHEMBL4727485) |
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| IC50 | 460±n/a nM |
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| Citation |  Alper, PB; Deane, J; Betschart, C; Buffet, D; Collignon Zipfel, G; Gordon, P; Hampton, J; Hawtin, S; Ibanez, M; Jiang, T; Junt, T; Knoepfel, T; Liu, B; Maginnis, J; McKeever, U; Michellys, PY; Mutnick, D; Nayak, B; Niwa, S; Richmond, W; Rush, JS; Syka, P; Zhang, Y; Zhu, X Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Toll-like receptor 9 |
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| Name: | Toll-like receptor 9 |
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| Synonyms: | CD_antigen=CD289 | TLR9_MOUSE | Tlr9 | Toll-like receptor 9 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 116449.39 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_101453 |
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| Residue: | 1032 |
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| Sequence: | MVLRRRTLHPLSLLVQAAVLAETLALGTLPAFLPCELKPHGLVDCNWLFLKSVPRFSAAA
SCSNITRLSLISNRIHHLHNSDFVHLSNLRQLNLKWNCPPTGLSPLHFSCHMTIEPRTFL
AMRTLEELNLSYNGITTVPRLPSSLVNLSLSHTNILVLDANSLAGLYSLRVLFMDGNCYY
KNPCTGAVKVTPGALLGLSNLTHLSLKYNNLTKVPRQLPPSLEYLLVSYNLIVKLGPEDL
ANLTSLRVLDVGGNCRRCDHAPNPCIECGQKSLHLHPETFHHLSHLEGLVLKDSSLHTLN
SSWFQGLVNLSVLDLSENFLYESITHTNAFQNLTRLRKLNLSFNYRKKVSFARLHLASSF
KNLVSLQELNMNGIFFRLLNKYTLRWLADLPKLHTLHLQMNFINQAQLSIFGTFRALRFV
DLSDNRISGPSTLSEATPEEADDAEQEELLSADPHPAPLSTPASKNFMDRCKNFKFTMDL
SRNNLVTIKPEMFVNLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWK
SFSELPQLQALDLSYNSQPFSMKGIGHNFSFVTHLSMLQSLSLAHNDIHTRVSSHLNSNS
VRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNLDNLPKSLKLLS
LRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTNGTLPNGTLLQKLDVSSNSIVSVVPA
FFALAVELKEVNLSHNILKTVDRSWFGPIVMNLTVLDVRSNPLHCACGAAFVDLLLEVQT
KVPGLANGVKCGSPGQLQGRSIFAQDLRLCLDEVLSWDCFGLSLLAVAVGMVVPILHHLC
GWDVWYCFHLCLAWLPLLARSRRSAQTLPYDAFVVFDKAQSAVADWVYNELRVRLEERRG
RRALRLCLEDRDWLPGQTLFENLWASIYGSRKTLFVLAHTDRVSGLLRTSFLLAQQRLLE
DRKDVVVLVILRPDAHRSRYVRLRQRLCRQSVLFWPQQPNGQGGFWAQLSTALTRDNRHF
YNQNFCRGPTAE
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| BDBM50560353 |
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| n/a |
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| Name | BDBM50560353 |
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| Synonyms: | CHEMBL4792072 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26FN5O |
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| Mol. Mass. | 395.4731 |
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| SMILES | Cc1cc(-c2ccc(OCC34CCC(N)(CC3)CC4)c(F)c2)c2cnc(N)nn12 |
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| Structure | 
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