Reaction Details |
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Target | Toll-like receptor 7 |
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Ligand | BDBM50560352 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2071952 (CHEMBL4727486) |
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IC50 | 200±n/a nM |
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Citation | Alper, PB; Deane, J; Betschart, C; Buffet, D; Collignon Zipfel, G; Gordon, P; Hampton, J; Hawtin, S; Ibanez, M; Jiang, T; Junt, T; Knoepfel, T; Liu, B; Maginnis, J; McKeever, U; Michellys, PY; Mutnick, D; Nayak, B; Niwa, S; Richmond, W; Rush, JS; Syka, P; Zhang, Y; Zhu, X Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Toll-like receptor 7 |
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Name: | Toll-like receptor 7 |
Synonyms: | ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7) |
Type: | Enzyme |
Mol. Mass.: | 120945.35 |
Organism: | Homo sapiens (Human) |
Description: | Q9NYK1 |
Residue: | 1049 |
Sequence: | MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV
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BDBM50560352 |
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n/a |
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Name | BDBM50560352 |
Synonyms: | CHEMBL4745239 |
Type | Small organic molecule |
Emp. Form. | C21H24FN5O2 |
Mol. Mass. | 397.446 |
SMILES | Cn1nc(-c2ccc(OCC34CCC(O)(CC3)CC4)c(F)c2)c2cnc(N)nc12 |
Structure |
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