| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prothrombin |
|---|
| Ligand | BDBM50123426 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_160975 |
|---|
| IC50 | 882±n/a nM |
|---|
| Citation |  Huang, W; Zhang, P; Zuckett, JF; Wang, L; Woolfrey, J; Song, Y; Jia, ZJ; Clizbe, LA; Su, T; Tran, K; Huang, B; Wong, P; Sinha, U; Park, G; Reed, A; Malinowski, J; Hollenbach, SJ; Scarborough, RM; Zhu, BY Design, synthesis and structure-activity relationships of benzoxazinone-based factor Xa inhibitors. Bioorg Med Chem Lett13:561-6 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prothrombin |
|---|
| Name: | Prothrombin |
|---|
| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 70029.57 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00734 |
|---|
| Residue: | 622 |
|---|
| Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
|
|
|
|---|
| BDBM50123426 |
|---|
| n/a |
|---|
| Name | BDBM50123426 |
|---|
| Synonyms: | 2-{7-[1-(1-Imino-ethyl)-piperidin-4-yloxy]-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-ylmethyl}-1-methyl-1H-indole-6-carboxamidine | CHEMBL152599 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H30N6O3 |
|---|
| Mol. Mass. | 474.5548 |
|---|
| SMILES | CC(=N)N1CCC(CC1)Oc1ccc2N(Cc3cc4ccc(cc4n3C)C(N)=N)C(=O)COc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
