| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
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| Ligand | BDBM50561464 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2074989 (CHEMBL4730523) |
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| IC50 | 90±n/a nM |
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| Citation |  Hiesinger, K; Kramer, JS; Beyer, S; Eckes, T; Brunst, S; Flauaus, C; Wittmann, SK; Weizel, L; Kaiser, A; Kretschmer, SBM; George, S; Angioni, C; Heering, J; Geisslinger, G; Schubert-Zsilavecz, M; Schmidtko, A; Pogoryelov, D; Pfeilschifter, J; Hofmann, B; Steinhilber, D; Schwalm, S; Proschak, E Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase. J Med Chem63:11498-11521 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional epoxide hydrolase 2 |
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| Name: | Bifunctional epoxide hydrolase 2 |
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| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic |
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| Type: | Enzyme |
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| Mol. Mass.: | 62613.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34913 |
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| Residue: | 555 |
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| Sequence: | MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL
SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA
ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV
VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS
APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT
PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH
KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK
WLDSDARNPPVVSKM
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| BDBM50561464 |
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| n/a |
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| Name | BDBM50561464 |
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| Synonyms: | CHEMBL4793032 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18F3N3O3 |
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| Mol. Mass. | 405.3704 |
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| SMILES | CC(C#Cc1cccc(c1)C(=O)NCc1ccccc1C(F)(F)F)N(O)C(N)=O |
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| Structure | 
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