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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fibroblast growth factor receptor 2 | ||
| Ligand | BDBM438598 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2075294 (CHEMBL4730828) | ||
| IC50 | 563±n/a nM | ||
| Citation |  Liu, H; Niu, D; Tham Sjin, RT; Dubrovskiy, A; Zhu, Z; McDonald, JJ; Fahnoe, K; Wang, Z; Munson, M; Scholte, A; Barrague, M; Fitzgerald, M; Liu, J; Kothe, M; Sun, F; Murtie, J; Ge, J; Rocnik, J; Harvey, D; Ospina, B; Perron, K; Zheng, G; Shehu, E; D'Agostino, LA Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma. ACS Med Chem Lett11:1899-1904 (2020) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fibroblast growth factor receptor 2 | |||
| Name: | Fibroblast growth factor receptor 2 | ||
| Synonyms: | BEK | CD_antigen=CD332 | FGFR-2 | FGFR-2 Tyrosine Kinase | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2) | Fibroblast growth factor receptor 2 precursor | KGFR | KSAM | Keratinocyte growth factor receptor | Keratinocyte growth factor receptor 2 | VEGF-receptor 2 and Fibroblast growth factor receptor 2 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 92015.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P21802 | ||
| Residue: | 821 | ||
| Sequence: |
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| BDBM438598 | |||
| n/a | |||
| Name | BDBM438598 | ||
| Synonyms: | US10618902, Compound I-279 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H23ClFN5O5 | ||
| Mol. Mass. | 503.911 | ||
| SMILES | COc1cc(OC)c(Cl)c(c1F)-c1cc2cnc(N[C@@H]3COC[C@@H]3NC(=O)C=C)nc2n(C)c1=O |r,wU:19.19,23.25,(9.16,-1.17,;9.16,.37,;7.82,1.14,;7.82,2.68,;6.49,3.45,;6.49,4.99,;7.82,5.76,;5.16,2.68,;3.82,3.45,;5.16,1.14,;6.49,.37,;6.49,-1.17,;3.82,.37,;2.49,1.14,;1.15,.37,;-.18,1.14,;-1.51,.37,;-1.51,-1.17,;-2.85,-1.94,;-4.18,-1.17,;-4.34,.36,;-5.85,.68,;-6.62,-.65,;-5.59,-1.8,;-5.91,-3.3,;-7.37,-3.78,;-8.52,-2.75,;-7.69,-5.28,;-9.16,-5.76,;-.18,-1.94,;1.15,-1.17,;2.49,-1.94,;2.49,-3.48,;3.82,-1.17,;5.16,-1.94,)| | ||
| Structure | 
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