Reaction Details |
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Target | Inosine-5'-monophosphate dehydrogenase 2 |
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Ligand | BDBM50126280 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_235 |
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IC50 | >1700±n/a nM |
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Citation | Chen, P; Norris, D; Haslow, KD; Murali Dhar, TG; Pitts, WJ; Watterson, SH; Cheney, DL; Bassolino, DA; Fleener, CA; Rouleau, KA; Hollenbaugh, DL; Townsend, RM; Barrish, JC; Iwanowicz, EJ Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors. Bioorg Med Chem Lett13:1345-8 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Inosine-5'-monophosphate dehydrogenase 2 |
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Name: | Inosine-5'-monophosphate dehydrogenase 2 |
Synonyms: | IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
Type: | Enzyme |
Mol. Mass.: | 55806.87 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant IMPDH2 expressed in E. coli. |
Residue: | 514 |
Sequence: | MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
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BDBM50126280 |
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n/a |
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Name | BDBM50126280 |
Synonyms: | 1-Cinnolin-6-yl-3-m-tolyl-urea | CHEMBL26025 |
Type | Small organic molecule |
Emp. Form. | C16H14N4O |
Mol. Mass. | 278.3086 |
SMILES | Cc1cccc(NC(=O)Nc2ccc3nnccc3c2)c1 |
Structure |
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