Found 85 hits with Last Name = 'townsend' and Initial = 'rm' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Integrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1
(Homo sapiens (Human)) | BDBM50199036
(4-[(5S,9R)-3-(3,5-dichloro-phenyl)-1-methyl-2,4-di...)Show SMILES CN1C(=O)N(C(=O)[C@]11CN(C[C@H]1c1ccc(cc1)C#N)C(=O)c1ccc2ncccc2c1)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C30H21Cl2N5O3/c1-35-29(40)37(24-13-22(31)12-23(32)14-24)28(39)30(35)17-36(16-25(30)19-6-4-18(15-33)5-7-19)27(38)21-8-9-26-20(11-21)3-2-10-34-26/h2-14,25H,16-17H2,1H3/t25-,30+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cerep
Curated by ChEMBL
| Assay Description
Inhibition of LFA1-mediated adhesion of T cell to HUVEC |
J Med Chem 49: 6946-9 (2006)
Article DOI: 10.1021/jm0610806
BindingDB Entry DOI: 10.7270/Q2SF2XC3 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50126275
(CHEMBL280793 | Isoquinolin-6-yl-(5-phenyl-oxazol-2...)Show InChI InChI=1S/C18H13N3O/c1-2-4-13(5-3-1)17-12-20-18(22-17)21-16-7-6-15-11-19-9-8-14(15)10-16/h1-12H,(H,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against inosine 5'-inosine monophosphate dehydrogenase type II (IMPDH II) |
Bioorg Med Chem Lett 13: 1345-8 (2003)
BindingDB Entry DOI: 10.7270/Q2CV4H3Q |
More data for this
Ligand-Target Pair | |
Integrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1
(Homo sapiens (Human)) | BDBM50199031
(4-[(5S,9R)-3-(3,5-dichloro-phenyl)-1-methyl-2,4-di...)Show SMILES CN1C(=O)N(C(=O)[C@]11CN(Cc2ccc3ncccc3c2)C[C@H]1c1ccc(cc1)C#N)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C30H23Cl2N5O2/c1-35-29(39)37(25-13-23(31)12-24(32)14-25)28(38)30(35)18-36(17-26(30)21-7-4-19(15-33)5-8-21)16-20-6-9-27-22(11-20)3-2-10-34-27/h2-14,26H,16-18H2,1H3/t26-,30+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Cerep
Curated by ChEMBL
| Assay Description
Inhibition of LFA1-mediated adhesion of T cell to HUVEC |
J Med Chem 49: 6946-9 (2006)
Article DOI: 10.1021/jm0610806
BindingDB Entry DOI: 10.7270/Q2SF2XC3 |
More data for this
Ligand-Target Pair | |
Integrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1
(Homo sapiens (Human)) | BDBM50199037
(4-[(5S,9R)-3-(3,5-dichloro-phenyl)-1-methyl-2,4-di...)Show SMILES CN1C(=O)N(C(=O)[C@]11CNCC1c1ccc(cc1)C#N)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C20H16Cl2N4O2/c1-25-19(28)26(16-7-14(21)6-15(22)8-16)18(27)20(25)11-24-10-17(20)13-4-2-12(9-23)3-5-13/h2-8,17,24H,10-11H2,1H3/t17?,20-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Cerep
Curated by ChEMBL
| Assay Description
Inhibition of LFA1-mediated adhesion of T cell to HUVEC |
J Med Chem 49: 6946-9 (2006)
Article DOI: 10.1021/jm0610806
BindingDB Entry DOI: 10.7270/Q2SF2XC3 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50123324
(7-Methoxy-6-oxazol-5-yl-2-phenyl-1H-quinolin-4-one...)Show InChI InChI=1S/C19H14N2O3/c1-23-18-9-16-13(7-14(18)19-10-20-11-24-19)17(22)8-15(21-16)12-5-3-2-4-6-12/h2-11H,1H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50112565
(CHEMBL25138 | N-tert-Butyl-N'-(3-methoxy-4-oxazol-...)Show InChI InChI=1S/C16H19N3O4/c1-16(2,3)19-15(21)14(20)18-10-5-6-11(12(7-10)22-4)13-8-17-9-23-13/h5-9H,1-4H3,(H,18,20)(H,19,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Integrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1
(Homo sapiens (Human)) | BDBM50199030
(4-[(5S,9R)-9-(4-cyano-phenyl)-3-(3,5-dichloro-phen...)Show SMILES CN1C(=O)N(C(=O)[C@]11CN(C[C@H]1c1ccc(cc1)C#N)S(=O)(=O)c1ccc(cc1)C(O)=O)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C27H20Cl2N4O6S/c1-31-26(37)33(21-11-19(28)10-20(29)12-21)25(36)27(31)15-32(14-23(27)17-4-2-16(13-30)3-5-17)40(38,39)22-8-6-18(7-9-22)24(34)35/h2-12,23H,14-15H2,1H3,(H,34,35)/t23-,27+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Cerep
Curated by ChEMBL
| Assay Description
Inhibition of LFA1-mediated adhesion of T cell to HUVEC |
J Med Chem 49: 6946-9 (2006)
Article DOI: 10.1021/jm0610806
BindingDB Entry DOI: 10.7270/Q2SF2XC3 |
More data for this
Ligand-Target Pair | |
Integrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1
(Homo sapiens (Human)) | BDBM50199035
(4-[(5S,9R)-3-(3,5-dichloro-phenyl)-7-isobutyl-1-me...)Show SMILES CC(C)CN1C[C@@H](c2ccc(cc2)C#N)[C@@]2(C1)N(C)C(=O)N(C2=O)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C24H24Cl2N4O2/c1-15(2)12-29-13-21(17-6-4-16(11-27)5-7-17)24(14-29)22(31)30(23(32)28(24)3)20-9-18(25)8-19(26)10-20/h4-10,15,21H,12-14H2,1-3H3/t21-,24+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Cerep
Curated by ChEMBL
| Assay Description
Inhibition of LFA1-mediated adhesion of T cell to HUVEC |
J Med Chem 49: 6946-9 (2006)
Article DOI: 10.1021/jm0610806
BindingDB Entry DOI: 10.7270/Q2SF2XC3 |
More data for this
Ligand-Target Pair | |
Integrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1
(Homo sapiens (Human)) | BDBM50199039
(4-[(5S,9R)-7-benzyl-3-(3,5-dichloro-phenyl)-1-meth...)Show SMILES CN1C(=O)N(C(=O)[C@]11CN(Cc2ccccc2)C[C@H]1c1ccc(cc1)C#N)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C27H22Cl2N4O2/c1-31-26(35)33(23-12-21(28)11-22(29)13-23)25(34)27(31)17-32(15-19-5-3-2-4-6-19)16-24(27)20-9-7-18(14-30)8-10-20/h2-13,24H,15-17H2,1H3/t24-,27+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Cerep
Curated by ChEMBL
| Assay Description
Inhibition of LFA1-mediated adhesion of T cell to HUVEC |
J Med Chem 49: 6946-9 (2006)
Article DOI: 10.1021/jm0610806
BindingDB Entry DOI: 10.7270/Q2SF2XC3 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50113230
(BMS-337197 | CHEMBL64830 | N-{2-[2-(3-Methoxy-4-ox...)Show SMILES COc1cc(Nc2ncc(o2)-c2ccccc2N(C)C(=O)CN2CCOCC2)ccc1-c1cnco1 Show InChI InChI=1S/C26H27N5O5/c1-30(25(32)16-31-9-11-34-12-10-31)21-6-4-3-5-19(21)24-15-28-26(36-24)29-18-7-8-20(22(13-18)33-2)23-14-27-17-35-23/h3-8,13-15,17H,9-12,16H2,1-2H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50126276
(1-Isoquinolin-6-yl-3-m-tolyl-urea | CHEMBL27948)Show InChI InChI=1S/C17H15N3O/c1-12-3-2-4-15(9-12)19-17(21)20-16-6-5-14-11-18-8-7-13(14)10-16/h2-11H,1H3,(H2,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against inosine 5'-inosine monophosphate dehydrogenase type II (IMPDH II) |
Bioorg Med Chem Lett 13: 1345-8 (2003)
BindingDB Entry DOI: 10.7270/Q2CV4H3Q |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50119045
(1-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-m-tolyl-urea ...)Show InChI InChI=1S/C18H17N3O3/c1-12-4-3-5-13(8-12)20-18(22)21-14-6-7-15(16(9-14)23-2)17-10-19-11-24-17/h3-11H,1-2H3,(H2,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50113224
((3-Methoxy-4-oxazol-5-yl-phenyl)-(5-phenyl-oxazol-...)Show InChI InChI=1S/C19H15N3O3/c1-23-16-9-14(7-8-15(16)18-10-20-12-24-18)22-19-21-11-17(25-19)13-5-3-2-4-6-13/h2-12H,1H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Integrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1
(Homo sapiens (Human)) | BDBM50199033
(5-[(5S,9R)-9-(4-CYANOPHENYL)-3-(3,5-DICHLOROPHENYL...)Show SMILES CN1C(=O)N(C(=O)[C@]11CN(Cc2cc(cs2)C(O)=O)C[C@H]1c1ccc(cc1)C#N)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C26H20Cl2N4O4S/c1-30-25(36)32(20-8-18(27)7-19(28)9-20)24(35)26(30)14-31(11-21-6-17(13-37-21)23(33)34)12-22(26)16-4-2-15(10-29)3-5-16/h2-9,13,22H,11-12,14H2,1H3,(H,33,34)/t22-,26+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Cerep
Curated by ChEMBL
| Assay Description
Inhibition of LFA1-mediated adhesion of T cell to HUVEC |
J Med Chem 49: 6946-9 (2006)
Article DOI: 10.1021/jm0610806
BindingDB Entry DOI: 10.7270/Q2SF2XC3 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129109
(CHEMBL62748 | N-{2-[2-(3-Bromo-4-oxazol-5-yl-pheny...)Show SMILES CN(C(=O)CO)c1ccccc1-c1cnc(Nc2ccc(-c3cnco3)c(Br)c2)o1 Show InChI InChI=1S/C21H17BrN4O4/c1-26(20(28)11-27)17-5-3-2-4-15(17)19-10-24-21(30-19)25-13-6-7-14(16(22)8-13)18-9-23-12-29-18/h2-10,12,27H,11H2,1H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129116
(2-Hydroxy-N-{2-[2-(3-methoxy-4-oxazol-5-yl-phenyla...)Show SMILES COc1cc(Nc2ncc(o2)-c2ccccc2N(C)C(=O)CO)ccc1-c1cnco1 Show InChI InChI=1S/C22H20N4O5/c1-26(21(28)12-27)17-6-4-3-5-15(17)20-11-24-22(31-20)25-14-7-8-16(18(9-14)29-2)19-10-23-13-30-19/h3-11,13,27H,12H2,1-2H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Integrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1
(Homo sapiens (Human)) | BDBM50199033
(5-[(5S,9R)-9-(4-CYANOPHENYL)-3-(3,5-DICHLOROPHENYL...)Show SMILES CN1C(=O)N(C(=O)[C@]11CN(Cc2cc(cs2)C(O)=O)C[C@H]1c1ccc(cc1)C#N)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C26H20Cl2N4O4S/c1-30-25(36)32(20-8-18(27)7-19(28)9-20)24(35)26(30)14-31(11-21-6-17(13-37-21)23(33)34)12-22(26)16-4-2-15(10-29)3-5-16/h2-9,13,22H,11-12,14H2,1H3,(H,33,34)/t22-,26+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Cerep
Curated by ChEMBL
| Assay Description
Inhibition of LFA1-mediated adhesion of T cell to HUVEC |
J Med Chem 49: 6946-9 (2006)
Article DOI: 10.1021/jm0610806
BindingDB Entry DOI: 10.7270/Q2SF2XC3 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129090
(CHEMBL305374 | N-{2-[2-(3-Bromo-4-oxazol-5-yl-phen...)Show SMILES CN(C(=O)CN1CCOCC1)c1ccccc1-c1cnc(Nc2ccc(-c3cnco3)c(Br)c2)o1 Show InChI InChI=1S/C25H24BrN5O4/c1-30(24(32)15-31-8-10-33-11-9-31)21-5-3-2-4-19(21)23-14-28-25(35-23)29-17-6-7-18(20(26)12-17)22-13-27-16-34-22/h2-7,12-14,16H,8-11,15H2,1H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50119033
((E)-3-Furan-2-yl-N-(3-methoxy-4-oxazol-5-yl-phenyl...)Show InChI InChI=1S/C17H14N2O4/c1-21-15-9-12(4-6-14(15)16-10-18-11-23-16)19-17(20)7-5-13-3-2-8-22-13/h2-11H,1H3,(H,19,20)/b7-5+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Integrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1
(Homo sapiens (Human)) | BDBM50199038
(4-[(5S,9R)-9-(4-cyano-phenyl)-3-(3,5-dichloro-phen...)Show SMILES CN1C(=O)N(C(=O)[C@]11CN(CCCC(O)=O)C[C@H]1c1ccc(cc1)C#N)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C24H22Cl2N4O4/c1-28-23(34)30(19-10-17(25)9-18(26)11-19)22(33)24(28)14-29(8-2-3-21(31)32)13-20(24)16-6-4-15(12-27)5-7-16/h4-7,9-11,20H,2-3,8,13-14H2,1H3,(H,31,32)/t20-,24+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Cerep
Curated by ChEMBL
| Assay Description
Inhibition of LFA1-mediated adhesion of T cell to HUVEC |
J Med Chem 49: 6946-9 (2006)
Article DOI: 10.1021/jm0610806
BindingDB Entry DOI: 10.7270/Q2SF2XC3 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129106
(CHEMBL63122 | N-{2-[2-(3-Chloro-4-oxazol-5-yl-phen...)Show SMILES CN(C(=O)CO)c1ccccc1-c1cnc(Nc2ccc(-c3cnco3)c(Cl)c2)o1 Show InChI InChI=1S/C21H17ClN4O4/c1-26(20(28)11-27)17-5-3-2-4-15(17)19-10-24-21(30-19)25-13-6-7-14(16(22)8-13)18-9-23-12-29-18/h2-10,12,27H,11H2,1H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129093
(2-Hydroxy-N-{2-[2-(3-methoxy-4-oxazol-4-yl-phenyla...)Show SMILES COc1cc(Nc2ncc(o2)-c2ccccc2N(C)C(=O)CO)ccc1-c1cocn1 Show InChI InChI=1S/C22H20N4O5/c1-26(21(28)11-27)18-6-4-3-5-16(18)20-10-23-22(31-20)25-14-7-8-15(19(9-14)29-2)17-12-30-13-24-17/h3-10,12-13,27H,11H2,1-2H3,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129095
(1-(3-Chloro-4-oxazol-5-yl-phenyl)-3-m-tolyl-urea |...)Show InChI InChI=1S/C17H14ClN3O2/c1-11-3-2-4-12(7-11)20-17(22)21-13-5-6-14(15(18)8-13)16-9-19-10-23-16/h2-10H,1H3,(H2,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129091
(CHEMBL62496 | N-Methyl-N-{2-[2-(3-methyl-4-oxazol-...)Show SMILES CN(C(=O)CN1CCOCC1)c1ccccc1-c1cnc(Nc2ccc(-c3cnco3)c(C)c2)o1 Show InChI InChI=1S/C26H27N5O4/c1-18-13-19(7-8-20(18)23-14-27-17-34-23)29-26-28-15-24(35-26)21-5-3-4-6-22(21)30(2)25(32)16-31-9-11-33-12-10-31/h3-8,13-15,17H,9-12,16H2,1-2H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129092
(CHEMBL293162 | N-{2-[2-(3-Chloro-4-oxazol-5-yl-phe...)Show SMILES CN(C(=O)CN1CCOCC1)c1ccccc1-c1cnc(Nc2ccc(-c3cnco3)c(Cl)c2)o1 Show InChI InChI=1S/C25H24ClN5O4/c1-30(24(32)15-31-8-10-33-11-9-31)21-5-3-2-4-19(21)23-14-28-25(35-23)29-17-6-7-18(20(26)12-17)22-13-27-16-34-22/h2-7,12-14,16H,8-11,15H2,1H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50112558
(CHEMBL24866 | N-(3-Bromo-4-oxazol-5-yl-phenyl)-N'-...)Show InChI InChI=1S/C15H16BrN3O3/c1-15(2,3)19-14(21)13(20)18-9-4-5-10(11(16)6-9)12-7-17-8-22-12/h4-8H,1-3H3,(H,18,20)(H,19,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50112568
(CHEMBL24092 | N-tert-Butyl-N'-(3-chloro-4-oxazol-5...)Show InChI InChI=1S/C15H16ClN3O3/c1-15(2,3)19-14(21)13(20)18-9-4-5-10(11(16)6-9)12-7-17-8-22-12/h4-8H,1-3H3,(H,18,20)(H,19,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129103
((3-Methoxy-4-oxazol-4-yl-phenyl)-(5-phenyl-oxazol-...)Show InChI InChI=1S/C19H15N3O3/c1-23-17-9-14(7-8-15(17)16-11-24-12-21-16)22-19-20-10-18(25-19)13-5-3-2-4-6-13/h2-12H,1H3,(H,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >57 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50126273
((5-Phenyl-oxazol-2-yl)-quinazolin-7-yl-amine | CHE...)Show InChI InChI=1S/C17H12N4O/c1-2-4-12(5-3-1)16-10-19-17(22-16)21-14-7-6-13-9-18-11-20-15(13)8-14/h1-11H,(H,19,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against inosine 5'-inosine monophosphate dehydrogenase type II (IMPDH II) |
Bioorg Med Chem Lett 13: 1345-8 (2003)
BindingDB Entry DOI: 10.7270/Q2CV4H3Q |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50116124
(CHEMBL433062 | N-(3-Methoxy-4-oxazol-5-yl-phenyl)-...)Show SMILES CNc1nc(Nc2ccc(-c3cnco3)c(OC)c2)nc(n1)-c1ccccc1 Show InChI InChI=1S/C20H18N6O2/c1-21-19-24-18(13-6-4-3-5-7-13)25-20(26-19)23-14-8-9-15(16(10-14)27-2)17-11-22-12-28-17/h3-12H,1-2H3,(H2,21,23,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129097
((3-Chloro-4-oxazol-5-yl-phenyl)-(5-phenyl-oxazol-2...)Show InChI InChI=1S/C18H12ClN3O2/c19-15-8-13(6-7-14(15)17-9-20-11-23-17)22-18-21-10-16(24-18)12-4-2-1-3-5-12/h1-11H,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129118
(CHEMBL302609 | N-{2-[2-(3-Methoxy-4-oxazol-4-yl-ph...)Show SMILES COc1cc(Nc2ncc(o2)-c2ccccc2N(C)C(=O)CN2CCOCC2)ccc1-c1cocn1 Show InChI InChI=1S/C26H27N5O5/c1-30(25(32)15-31-9-11-34-12-10-31)22-6-4-3-5-20(22)24-14-27-26(36-24)29-18-7-8-19(23(13-18)33-2)21-16-35-17-28-21/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H,27,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129100
(2-Hydroxy-N-methyl-N-{2-[2-(3-methyl-4-oxazol-5-yl...)Show SMILES CN(C(=O)CO)c1ccccc1-c1cnc(Nc2ccc(-c3cnco3)c(C)c2)o1 Show InChI InChI=1S/C22H20N4O4/c1-14-9-15(7-8-16(14)19-10-23-13-29-19)25-22-24-11-20(30-22)17-5-3-4-6-18(17)26(2)21(28)12-27/h3-11,13,27H,12H2,1-2H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129089
(CHEMBL62467 | N-{2-[2-(3-Ethyl-4-oxazol-5-yl-pheny...)Show SMILES CCc1cc(Nc2ncc(o2)-c2ccccc2N(C)C(=O)CO)ccc1-c1cnco1 Show InChI InChI=1S/C23H22N4O4/c1-3-15-10-16(8-9-17(15)20-11-24-14-30-20)26-23-25-12-21(31-23)18-6-4-5-7-19(18)27(2)22(29)13-28/h4-12,14,28H,3,13H2,1-2H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50126265
(1-Quinazolin-7-yl-3-m-tolyl-urea | CHEMBL26741)Show InChI InChI=1S/C16H14N4O/c1-11-3-2-4-13(7-11)19-16(21)20-14-6-5-12-9-17-10-18-15(12)8-14/h2-10H,1H3,(H2,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against inosine 5'-inosine monophosphate dehydrogenase type II (IMPDH II) |
Bioorg Med Chem Lett 13: 1345-8 (2003)
BindingDB Entry DOI: 10.7270/Q2CV4H3Q |
More data for this
Ligand-Target Pair | |
Integrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1
(Homo sapiens (Human)) | BDBM50199032
(4-[(5S,9R)-9-(4-cyano-phenyl)-3-(3,5-dichloro-phen...)Show SMILES CN1C(=O)N(C(=O)[C@]11CN(C[C@H]1c1ccc(cc1)C#N)C(=O)CCC(O)=O)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C24H20Cl2N4O5/c1-28-23(35)30(18-9-16(25)8-17(26)10-18)22(34)24(28)13-29(20(31)6-7-21(32)33)12-19(24)15-4-2-14(11-27)3-5-15/h2-5,8-10,19H,6-7,12-13H2,1H3,(H,32,33)/t19-,24+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 164 | n/a | n/a | n/a | n/a | n/a | n/a |
Cerep
Curated by ChEMBL
| Assay Description
Inhibition of LFA1-mediated adhesion of T cell to HUVEC |
J Med Chem 49: 6946-9 (2006)
Article DOI: 10.1021/jm0610806
BindingDB Entry DOI: 10.7270/Q2SF2XC3 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129107
((3-Methoxy-4-oxazol-2-yl-phenyl)-(5-phenyl-oxazol-...)Show InChI InChI=1S/C19H15N3O3/c1-23-16-11-14(7-8-15(16)18-20-9-10-24-18)22-19-21-12-17(25-19)13-5-3-2-4-6-13/h2-12H,1H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129120
(7-Methoxy-6-oxazol-4-yl-2-phenyl-1H-quinolin-4-one...)Show InChI InChI=1S/C19H14N2O3/c1-23-19-9-16-13(7-14(19)17-10-24-11-20-17)18(22)8-15(21-16)12-5-3-2-4-6-12/h2-11H,1H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50119130
(CHEMBL60730 | N''-cyano-N-[3-methoxy-4-(1,3-oxazol...)Show SMILES COc1cc(NC(Nc2ccccc2)=NC#N)ccc1-c1cnco1 |w:14.15| Show InChI InChI=1S/C18H15N5O2/c1-24-16-9-14(7-8-15(16)17-10-20-12-25-17)23-18(21-11-19)22-13-5-3-2-4-6-13/h2-10,12H,1H3,(H2,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50126283
(1-Isoquinolin-6-yl-3-p-tolyl-urea | CHEMBL29927)Show InChI InChI=1S/C17H15N3O/c1-12-2-5-15(6-3-12)19-17(21)20-16-7-4-14-11-18-9-8-13(14)10-16/h2-11H,1H3,(H2,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 247 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against inosine 5'-inosine monophosphate dehydrogenase type II (IMPDH II) |
Bioorg Med Chem Lett 13: 1345-8 (2003)
BindingDB Entry DOI: 10.7270/Q2CV4H3Q |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129110
(CHEMBL62747 | N-{2-[2-(3-Ethyl-4-oxazol-5-yl-pheny...)Show SMILES CCc1cc(Nc2ncc(o2)-c2ccccc2N(C)C(=O)CN2CCOCC2)ccc1-c1cnco1 Show InChI InChI=1S/C27H29N5O4/c1-3-19-14-20(8-9-21(19)24-15-28-18-35-24)30-27-29-16-25(36-27)22-6-4-5-7-23(22)31(2)26(33)17-32-10-12-34-13-11-32/h4-9,14-16,18H,3,10-13,17H2,1-2H3,(H,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Integrin alpha-L/Integrin beta-2/Intercellular adhesion molecule 1
(Homo sapiens (Human)) | BDBM50199034
(5-[(5R,9S)-9-(4-cyano-phenyl)-3-(3,5-dichloro-phen...)Show SMILES CN1C(=O)N(C(=O)[C@@]11CN(Cc2cc(cs2)C(O)=O)C[C@@H]1c1ccc(cc1)C#N)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C26H20Cl2N4O4S/c1-30-25(36)32(20-8-18(27)7-19(28)9-20)24(35)26(30)14-31(11-21-6-17(13-37-21)23(33)34)12-22(26)16-4-2-15(10-29)3-5-16/h2-9,13,22H,11-12,14H2,1H3,(H,33,34)/t22-,26+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Cerep
Curated by ChEMBL
| Assay Description
Inhibition of LFA1-mediated adhesion of T cell to HUVEC |
J Med Chem 49: 6946-9 (2006)
Article DOI: 10.1021/jm0610806
BindingDB Entry DOI: 10.7270/Q2SF2XC3 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129113
(CHEMBL65970 | N-(3-Chloro-4-oxazol-5-yl-phenyl)-N'...)Show SMILES CNc1nc(Nc2ccc(-c3cnco3)c(Cl)c2)nc(n1)-c1ccccc1 Show InChI InChI=1S/C19H15ClN6O/c1-21-18-24-17(12-5-3-2-4-6-12)25-19(26-18)23-13-7-8-14(15(20)9-13)16-10-22-11-27-16/h2-11H,1H3,(H2,21,23,24,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >340 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50126285
(1-Benzyl-3-isoquinolin-6-yl-urea | CHEMBL29926)Show InChI InChI=1S/C17H15N3O/c21-17(19-11-13-4-2-1-3-5-13)20-16-7-6-15-12-18-9-8-14(15)10-16/h1-10,12H,11H2,(H2,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against inosine 5'-inosine monophosphate dehydrogenase type II (IMPDH II) |
Bioorg Med Chem Lett 13: 1345-8 (2003)
BindingDB Entry DOI: 10.7270/Q2CV4H3Q |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129099
((3-Methoxy-4-[1,2,4]triazol-1-yl-phenyl)-(5-phenyl...)Show InChI InChI=1S/C18H15N5O2/c1-24-16-9-14(7-8-15(16)23-12-19-11-21-23)22-18-20-10-17(25-18)13-5-3-2-4-6-13/h2-12H,1H3,(H,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129112
(1-[4-(4-Methyl-oxazol-5-yl)-phenyl]-3-m-tolyl-urea...)Show InChI InChI=1S/C18H17N3O2/c1-12-4-3-5-16(10-12)21-18(22)20-15-8-6-14(7-9-15)17-13(2)19-11-23-17/h3-11H,1-2H3,(H2,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50126284
(5-Bromo-isoquinolin-6-ylamine | CHEMBL27011)Show InChI InChI=1S/C9H7BrN2/c10-9-7-3-4-12-5-6(7)1-2-8(9)11/h1-5H,11H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against inosine 5'-inosine monophosphate dehydrogenase type II (IMPDH II) |
Bioorg Med Chem Lett 13: 1345-8 (2003)
BindingDB Entry DOI: 10.7270/Q2CV4H3Q |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50129101
(1-(4-Oxazol-5-yl-phenyl)-3-m-tolyl-urea | CHEMBL62...)Show InChI InChI=1S/C17H15N3O2/c1-12-3-2-4-15(9-12)20-17(21)19-14-7-5-13(6-8-14)16-10-18-11-22-16/h2-11H,1H3,(H2,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of inosine-5'-monophosphate dehydrogenase 2. |
Bioorg Med Chem Lett 13: 2059-63 (2003)
BindingDB Entry DOI: 10.7270/Q22Z14X1 |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50126268
(1-Isoquinolin-6-yl-3-phenyl-urea | CHEMBL27529)Show InChI InChI=1S/C16H13N3O/c20-16(18-14-4-2-1-3-5-14)19-15-7-6-13-11-17-9-8-12(13)10-15/h1-11H,(H2,18,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against inosine 5'-inosine monophosphate dehydrogenase type II (IMPDH II) |
Bioorg Med Chem Lett 13: 1345-8 (2003)
BindingDB Entry DOI: 10.7270/Q2CV4H3Q |
More data for this
Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase 2
(Homo sapiens (Human)) | BDBM50126282
(1-(5-Bromo-isoquinolin-6-yl)-3-phenyl-urea | CHEMB...)Show InChI InChI=1S/C16H12BrN3O/c17-15-13-8-9-18-10-11(13)6-7-14(15)20-16(21)19-12-4-2-1-3-5-12/h1-10H,(H2,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity of the compound against inosine 5'-inosine monophosphate dehydrogenase type II (IMPDH II) |
Bioorg Med Chem Lett 13: 1345-8 (2003)
BindingDB Entry DOI: 10.7270/Q2CV4H3Q |
More data for this
Ligand-Target Pair | |
Search and Browse
