| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine kinase 1 |
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| Ligand | BDBM50041978 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2080389 (CHEMBL4736180) |
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| Ki | 3.6±n/a nM |
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| Citation |  Congdon, M; Fritzemeier, RG; Kharel, Y; Brown, AM; Serbulea, V; Bevan, DR; Lynch, KR; Santos, WL Probing the substitution pattern of indole-based scaffold reveals potent and selective sphingosine kinase 2 inhibitors. Eur J Med Chem212:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine kinase 1 |
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| Name: | Sphingosine kinase 1 |
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| Synonyms: | SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 42521.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NYA1 |
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| Residue: | 384 |
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| Sequence: | MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHA
RELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASL
NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE
SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVP
LEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLL
RLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFW
MVSGCVEPPPSWKPQQMPPPEEPL
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| BDBM50041978 |
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| n/a |
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| Name | BDBM50041978 |
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| Synonyms: | CHEMBL3134157 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H31NO4S |
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| Mol. Mass. | 465.604 |
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| SMILES | Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc(CN3CCC[C@@H]3CO)cc2)c1 |r| |
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| Structure | 
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