| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein kinase C theta type |
|---|
| Ligand | BDBM50563323 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2081937 (CHEMBL4737728) |
|---|
| Ki | 134±n/a nM |
|---|
| Citation |  Yu, M; Teo, T; Yang, Y; Li, M; Long, Y; Philip, S; Noll, B; Heinemann, GK; Diab, S; Eldi, P; Mekonnen, L; Anshabo, AT; Rahaman, MH; Milne, R; Hayball, JD; Wang, S Potent and orally bioavailable CDK8 inhibitors: Design, synthesis, structure-activity relationship analysis and biological evaluation. Eur J Med Chem214:0 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein kinase C theta type |
|---|
| Name: | Protein kinase C theta type |
|---|
| Synonyms: | KPCT_HUMAN | PRKCQ | PRKCT | Protein kinase C theta | Protein kinase C theta type (PRKCQ) | Protein kinase C, PKC; classical/novel | nPKC-theta |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 81878.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Full-length human PKC theta (Panvera Catalog No. P2996). |
|---|
| Residue: | 706 |
|---|
| Sequence: | MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF
DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR
YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV
WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK
SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ
ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP
EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD
DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR
ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC
GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR
WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD
CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS
|
|
|
|---|
| BDBM50563323 |
|---|
| n/a |
|---|
| Name | BDBM50563323 |
|---|
| Synonyms: | CHEMBL4791586 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H20ClN3OS |
|---|
| Mol. Mass. | 397.921 |
|---|
| SMILES | Clc1cncc(-c2cc3ccccc3s2)c1N1CCC2(CCNC2=O)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
