Reaction Details | |||
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Target | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | ||
Ligand | BDBM198042 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2084621 (CHEMBL4765884) | ||
IC50 | 160±n/a nM | ||
Citation | Patel, L; Chandrasekhar, J; Evarts, J; Forseth, K; Haran, AC; Ip, C; Kashishian, A; Kim, M; Koditek, D; Koppenol, S; Lad, L; Lepist, EI; McGrath, ME; Perreault, S; Puri, KD; Villaseņor, AG; Somoza, JR; Steiner, BH; Therrien, J; Treiberg, J; Phillips, G Discovery of Orally Efficacious Phosphoinositide 3-Kinase ? Inhibitors with Improved Metabolic Stability. J Med Chem59:9228-9242 (2016) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | |||
Name: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | ||
Synonyms: | PI3-kinase p110 subunit gamma | PI3-kinase subunit p120-gamma | PI3Kgamma | PIK3CG | PK3CG_HUMAN | Phosphatidylinositol 4,5-biphosphate 3-kinase catalytic subunit gamma (PIK3CG) | Phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) | Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma (PI3K gamma) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma (PI3Kgamma) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3K gamma) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3K) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3Kgamma) | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Phosphoinositide 3-Kinase (PI3K), gamma Chain A | Phosphoinositide 3-kinases gamma (PI3K gamma) | Phosphoinositide-3-kinase (PI3K gamma) | p120-PI3K | ||
Type: | Enzyme Subunit | ||
Mol. Mass.: | 126470.30 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P48736 | ||
Residue: | 1102 | ||
Sequence: |
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BDBM198042 | |||
n/a | |||
Name | BDBM198042 | ||
Synonyms: | BDBM198043 | US9221795, 38 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H18ClN9O | ||
Mol. Mass. | 447.88 | ||
SMILES | C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(Cl)c2c(=O)n1-c1cccnc1C |r,wD:1.0,(2,1.15,;.67,.38,;.67,-1.16,;2,-1.93,;3.33,-1.16,;4.67,-1.93,;6,-1.15,;4.67,-3.47,;3.33,-4.23,;3.33,-5.78,;2,-3.47,;.67,-4.24,;-.67,-5.01,;-.67,1.15,;-2,.38,;-3.33,1.15,;-4.67,.38,;-6,1.15,;-6,2.69,;-4.67,3.46,;-4.67,5,;-3.33,2.69,;-2,3.46,;-2,5,;-.67,2.69,;.67,3.46,;2,2.69,;3.33,3.46,;3.33,5,;2,5.78,;.67,5,;-.67,5.77,)| | ||
Structure |