| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM294372 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2085845 (CHEMBL4767108) |
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| IC50 | >100000±n/a nM |
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| Citation |  Ko, K; Kim, HJ; Ho, PS; Lee, SO; Lee, JE; Min, CR; Kim, YC; Yoon, JH; Park, EJ; Kwon, YJ; Yun, JH; Yoon, DO; Kim, JS; Park, WS; Oh, SS; Song, YM; Cho, WK; Morikawa, K; Lee, KJ; Park, CH Discovery of a Novel Highly Selective Histamine H4 Receptor Antagonist for the Treatment of Atopic Dermatitis. J Med Chem61:2949-2961 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM294372 |
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| n/a |
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| Name | BDBM294372 |
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| Synonyms: | US9586959, Compound 23 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H18ClN7O |
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| Mol. Mass. | 347.803 |
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| SMILES | CCOc1nc2nc(N3CCN(C)CC3)c3nncn3c2cc1Cl |
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| Structure | 
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