| Reaction Details |
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 | Report a problem with these data |
| Target | Inosine-5'-monophosphate dehydrogenase 2 |
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| Ligand | BDBM50112570 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_89803 |
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| IC50 | >5000±n/a nM |
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| Citation |  Iwanowicz, EJ; Watterson, SH; Guo, J; Pitts, WJ; Murali Dhar, TG; Shen, Z; Chen, P; Gu, HH; Fleener, CA; Rouleau, KA; Cheney, DL; Townsend, RM; Hollenbaugh, DL Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety. Bioorg Med Chem Lett13:2059-63 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Inosine-5'-monophosphate dehydrogenase 2 |
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| Name: | Inosine-5'-monophosphate dehydrogenase 2 |
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| Synonyms: | IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55806.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant IMPDH2 expressed in E. coli. |
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| Residue: | 514 |
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| Sequence: | MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
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| BDBM50112570 |
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| n/a |
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| Name | BDBM50112570 |
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| Synonyms: | CHEMBL279957 | N-tert-Butyl-N'-[4-(4-methyl-oxazol-5-yl)-phenyl]-oxalamide |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19N3O3 |
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| Mol. Mass. | 301.3404 |
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| SMILES | Cc1ncoc1-c1ccc(NC(=O)C(=O)NC(C)(C)C)cc1 |
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| Structure | 
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