Reaction Details |
| Report a problem with these data |
Target | DNA topoisomerase 1 |
---|
Ligand | BDBM50510251 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2091069 (CHEMBL4772332) |
---|
IC50 | >10000±n/a nM |
---|
Citation | Kundu, B; Sarkar, D; Chowdhuri, SP; Pal, S; Das, SK; Das, BB; Talukdar, A Development of a metabolically stable topoisomerase I poison as anticancer agent. Eur J Med Chem202:0 (2020) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
DNA topoisomerase 1 |
---|
Name: | DNA topoisomerase 1 |
Synonyms: | DNA topoisomerase I | DNA topoisomerase I (Topo I) | TOP1 | TOP1_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 90771.02 |
Organism: | Homo sapiens (Human) |
Description: | P11387 |
Residue: | 765 |
Sequence: | MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKK
HKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEP
EDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKD
KDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKF
YYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKC
DFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL
FRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENI
QGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALY
FIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNK
VPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ
QLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLAD
ARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSK
LNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
|
|
|
BDBM50510251 |
---|
n/a |
---|
Name | BDBM50510251 |
Synonyms: | CHEMBL4585353 |
Type | Small organic molecule |
Emp. Form. | C23H20N6O |
Mol. Mass. | 396.4445 |
SMILES | C(CNc1c(cnc2ccc(cc12)-c1ccccc1)-c1nnco1)Cn1ccnc1 |
Structure |
|