| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2C19 |
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| Ligand | BDBM50566354 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2100083 (CHEMBL4808479) |
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| IC50 | >20000±n/a nM |
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| Citation |  Priebbenow, DL; Mathiew, M; Shi, DH; Harjani, JR; Beveridge, JG; Chavchich, M; Edstein, MD; Duffy, S; Avery, VM; Jacobs, RT; Brand, S; Shackleford, DM; Wang, W; Zhong, L; Lee, G; Tay, E; Barker, H; Crighton, E; White, KL; Charman, SA; De Paoli, A; Creek, DJ; Baell, JB Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines. J Med Chem64:4150-4162 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2C19 |
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| Name: | Cytochrome P450 2C19 |
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| Synonyms: | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | CP2CJ_HUMAN | CYP2C19 | CYPIIC17 | CYPIIC19 | Cytochrome P450 2C19 (CYP2C19) | Cytochrome P450 2C19 [I331V] | Cytochrome P450-11A | Cytochrome P450-254C | Fenbendazole monooxygenase (4'-hydroxylating) | Mephenytoin 4-hydroxylase | P450-11A | P450-254C |
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| Type: | Enzyme |
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| Mol. Mass.: | 55935.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P33261 |
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| Residue: | 490 |
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| Sequence: | MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI
YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM
ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYID
LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK
KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP
PFYQLCFIPV
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| BDBM50566354 |
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| n/a |
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| Name | BDBM50566354 |
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| Synonyms: | CHEMBL4853103 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H19N7O2 |
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| Mol. Mass. | 305.3357 |
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| SMILES | CCCOc1nncc(n1)-c1cnnc(OCCN(C)C)n1 |
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| Structure | 
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