| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform epsilon |
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| Ligand | BDBM50568545 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2105812 (CHEMBL4814487) |
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| IC50 | 180±n/a nM |
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| Citation |  Bazin, MA; Cojean, S; Pagniez, F; Bernadat, G; Cav, C; Ourliac-Garnier, I; Nourrisson, MR; Morgado, C; Picot, C; Leclercq, O; Baratte, B; Robert, T; Spth, GF; Rachidi, N; Bach, S; Loiseau, PM; Le Pape, P; Marchand, P Invitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L.major casein kinase 1 inhibition. Eur J Med Chem210:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform epsilon |
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| Name: | Casein kinase I isoform epsilon |
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| Synonyms: | Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Æ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 47340.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49674 |
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| Residue: | 416 |
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| Sequence: | MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
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| BDBM50568545 |
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| n/a |
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| Name | BDBM50568545 |
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| Synonyms: | CHEMBL4877608 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13FN6S |
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| Mol. Mass. | 352.389 |
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| SMILES | CSc1nccc(n1)-c1c(nc2c(N)nccn12)-c1ccc(F)cc1 |
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| Structure | 
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