| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lactoylglutathione lyase |
|---|
| Ligand | BDBM50569130 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2108109 (CHEMBL4816784) |
|---|
| IC50 | 3400±n/a nM |
|---|
| Citation |  Azuma, M; Inoue, M; Nishida, A; Akahane, H; Kitajima, M; Natani, S; Chimori, R; Yoshimori, A; Mano, Y; Uchiro, H; Tanuma, SI; Takasawa, R Addition of hydrophobic side chains improve the apoptosis inducibility of the human glyoxalase I inhibitor, TLSC702. Bioorg Med Chem Lett40:0 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lactoylglutathione lyase |
|---|
| Name: | Lactoylglutathione lyase |
|---|
| Synonyms: | Aldoketomutase | GLO1 | Glx I | Glyoxalase 1 (GLO1) | Glyoxalase I | Ketone-aldehyde mutase | LGUL_HUMAN | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 20772.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q04760 |
|---|
| Residue: | 184 |
|---|
| Sequence: | MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQK
CDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNS
DPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKM
ATLM
|
|
|
|---|
| BDBM50569130 |
|---|
| n/a |
|---|
| Name | BDBM50569130 |
|---|
| Synonyms: | CHEMBL1303934 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H13NO4S |
|---|
| Mol. Mass. | 339.365 |
|---|
| SMILES | OC(=O)C\C(=C/c1ccc2OCOc2c1)c1nc2ccccc2s1 |
|---|
| Structure | 
|
|---|
Search and Browse
