| Reaction Details |
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 | Report a problem with these data |
| Target | Lactoylglutathione lyase |
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| Ligand | BDBM54054 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2108109 (CHEMBL4816784) |
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| IC50 | 5300±n/a nM |
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| Citation |  Azuma, M; Inoue, M; Nishida, A; Akahane, H; Kitajima, M; Natani, S; Chimori, R; Yoshimori, A; Mano, Y; Uchiro, H; Tanuma, SI; Takasawa, R Addition of hydrophobic side chains improve the apoptosis inducibility of the human glyoxalase I inhibitor, TLSC702. Bioorg Med Chem Lett40:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lactoylglutathione lyase |
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| Name: | Lactoylglutathione lyase |
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| Synonyms: | Aldoketomutase | GLO1 | Glx I | Glyoxalase 1 (GLO1) | Glyoxalase I | Ketone-aldehyde mutase | LGUL_HUMAN | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase |
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| Type: | Enzyme |
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| Mol. Mass.: | 20772.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q04760 |
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| Residue: | 184 |
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| Sequence: | MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQK
CDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNS
DPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKM
ATLM
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| BDBM54054 |
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| n/a |
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| Name | BDBM54054 |
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| Synonyms: | (E)-3-(1,3-benzoxazol-2-yl)-4-(4-methoxyphenyl)-3-butenoic acid | (E)-3-(1,3-benzoxazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic acid | MLS000760613 | SMR000370669 | cid_6224224 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15NO4 |
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| Mol. Mass. | 309.316 |
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| SMILES | COc1ccc(\C=C(/CC(O)=O)c2nc3ccccc3o2)cc1 |
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| Structure | 
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