| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 2 |
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| Ligand | BDBM50258579 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2109867 (CHEMBL4818542) |
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| IC50 | 7.0±n/a nM |
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| Citation |  Beshore, DC; Adam, GC; Barnard, RJO; Burlein, C; Gallicchio, SN; Holloway, MK; Krosky, D; Lemaire, W; Myers, RW; Patel, S; Plotkin, MA; Powell, DA; Rada, V; Cox, CD; Coleman, PJ; Klein, DJ; Wolkenberg, SE Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction. ACS Med Chem Lett12:540-547 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 2 |
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| Name: | Histone deacetylase 2 |
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| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
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| Type: | Chromatin regulator; hydrolase; repressor |
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| Mol. Mass.: | 55356.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92769 |
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| Residue: | 488 |
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| Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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| BDBM50258579 |
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| n/a |
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| Name | BDBM50258579 |
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| Synonyms: | (S)-N-(1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-oxooctyl)-1-methylazetidine-3-carboxamide | CHEMBL2448576 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H35N5O3 |
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| Mol. Mass. | 477.5985 |
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| SMILES | CCC(=O)CCCCC[C@H](NC(=O)C1CN(C)C1)c1ncc([nH]1)-c1cc2ccccc2nc1OC |r| |
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| Structure | 
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