Reaction Details |
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Target | Histone deacetylase 3 |
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Ligand | BDBM25150 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2109868 (CHEMBL4818543) |
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IC50 | 7.3±n/a nM |
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Citation | Beshore, DC; Adam, GC; Barnard, RJO; Burlein, C; Gallicchio, SN; Holloway, MK; Krosky, D; Lemaire, W; Myers, RW; Patel, S; Plotkin, MA; Powell, DA; Rada, V; Cox, CD; Coleman, PJ; Klein, DJ; Wolkenberg, SE Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction. ACS Med Chem Lett12:540-547 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 3 |
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Name: | Histone deacetylase 3 |
Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
Type: | Enzyme |
Mol. Mass.: | 48829.55 |
Organism: | Homo sapiens (Human) |
Description: | O15379 |
Residue: | 428 |
Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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BDBM25150 |
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n/a |
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Name | BDBM25150 |
Synonyms: | (2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide | Belinosta | Belinostat | PXD-101 | PXD101 |
Type | Small organic molecule |
Emp. Form. | C15H14N2O4S |
Mol. Mass. | 318.348 |
SMILES | ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)Nc1ccccc1 |
Structure |
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