Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM50571377

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2114591 (CHEMBL4823532)

EC50

398±n/a nM

Citation

Narayanan, S; Wang, S; Vasukuttan, V; Vyas Devambatla, RK; Dai, D; Jin, C; Snyder, R; Laudermilk, L; Runyon, SP; Maitra, R Pyrazole Agonist of the Apelin Receptor Improves Symptoms of Metabolic Syndrome in Mice. J Med Chem64:3006-3025 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM50571377

n/a

Name

BDBM50571377

Synonyms:

CHEMBL4847403

Type

Small organic molecule

Emp. Form.

C26H37ClN4O5

Mol. Mass.

521.049

SMILES

Cl.COc1cccc(OC)c1-c1cc(nn1C1CCCC1)C(=O)N[C@@H](CCN1CCCC1)CC(O)=O |r,wU:24.26,(42.95,-13.48,;33.36,-11.74,;34.51,-12.77,;34.19,-14.27,;32.72,-14.75,;32.4,-16.26,;33.56,-17.29,;35.02,-16.81,;36.17,-17.83,;35.85,-19.34,;35.33,-15.3,;36.79,-14.83,;37.26,-13.36,;38.8,-13.36,;39.28,-14.82,;38.03,-15.73,;38.04,-17.27,;36.8,-18.18,;37.27,-19.64,;38.81,-19.64,;39.29,-18.18,;39.7,-12.11,;39.07,-10.71,;41.24,-12.27,;42.14,-11.02,;41.51,-9.62,;42.41,-8.37,;41.78,-6.96,;42.56,-5.63,;41.52,-4.49,;40.12,-5.12,;40.28,-6.65,;43.67,-11.18,;44.57,-9.93,;46.11,-10.09,;43.94,-8.53,)|

Structure