Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM50571376

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2114593 (CHEMBL4823534)

EC50

>10000±n/a nM

Citation

Narayanan, S; Wang, S; Vasukuttan, V; Vyas Devambatla, RK; Dai, D; Jin, C; Snyder, R; Laudermilk, L; Runyon, SP; Maitra, R Pyrazole Agonist of the Apelin Receptor Improves Symptoms of Metabolic Syndrome in Mice. J Med Chem64:3006-3025 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM50571376

n/a

Name

BDBM50571376

Synonyms:

CHEMBL4869477

Type

Small organic molecule

Emp. Form.

C26H39ClN4O5

Mol. Mass.

523.065

SMILES

Cl.CCN(CC)CC[C@@H](CC(O)=O)NC(=O)c1cc(-c2c(OC)cccc2OC)n(n1)C1CCCC1 |r,wU:8.6,(26.45,-12.76,;25.46,-3.21,;26.08,-4.61,;25.17,-5.86,;23.65,-5.7,;23.02,-4.29,;25.8,-7.27,;24.9,-8.51,;25.52,-9.92,;27.06,-10.08,;27.96,-8.83,;29.49,-8.99,;27.33,-7.42,;24.62,-11.17,;23.09,-11.01,;22.46,-9.6,;22.19,-12.25,;20.65,-12.26,;20.17,-13.72,;18.72,-14.2,;17.57,-13.17,;17.89,-11.66,;16.75,-10.63,;16.11,-13.64,;15.79,-15.15,;16.95,-16.18,;18.4,-15.7,;19.55,-16.73,;19.24,-18.23,;21.42,-14.63,;22.66,-13.72,;21.43,-16.16,;20.19,-17.07,;20.66,-18.53,;22.2,-18.53,;22.68,-17.07,)|

Structure