| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase receptor TYRO3 |
|---|
| Ligand | BDBM50571440 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2114656 (CHEMBL4823597) |
|---|
| IC50 | 1.000000±n/a nM |
|---|
| Citation |  Zhang, H; Peng, X; Dai, Y; Shao, J; Ji, Y; Sun, Y; Liu, B; Cheng, X; Ai, J; Duan, W Discovery of a Pyrimidinedione Derivative as a Potent and Orally Bioavailable Axl Inhibitor. J Med Chem64:3956-3975 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase receptor TYRO3 |
|---|
| Name: | Tyrosine-protein kinase receptor TYRO3 |
|---|
| Synonyms: | BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 96894.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q06418 |
|---|
| Residue: | 890 |
|---|
| Sequence: | MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPV
KLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVE
DGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKI
GGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSN
ASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRC
ANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKL
SWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQ
GPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAA
RSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQE
DGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPM
VILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARN
CMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGV
TMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFT
CLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAV
GGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
|
|
|
|---|
| BDBM50571440 |
|---|
| n/a |
|---|
| Name | BDBM50571440 |
|---|
| Synonyms: | CHEMBL4873571 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H25F2N5O5 |
|---|
| Mol. Mass. | 561.5361 |
|---|
| SMILES | CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
