| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50573545 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2119723 (CHEMBL4828870) |
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| Ki | 4000±n/a nM |
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| Citation |  Salerno, S; Amendola, G; Angeli, A; Baglini, E; Barresi, E; Marini, AM; Ravichandran, R; Viviano, M; Castellano, S; Novellino, E; Da Settimo, F; Supuran, CT; Cosconati, S; Taliani, S Inhibition studies on carbonic anhydrase isoforms I, II, IV and IX with N-arylsubstituted secondary sulfonamides featuring a bicyclic tetrahydroindazole scaffold. Eur J Med Chem220:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50573545 |
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| n/a |
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| Name | BDBM50573545 |
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| Synonyms: | CHEMBL4853204 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23N3O3S |
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| Mol. Mass. | 409.501 |
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| SMILES | Cc1ccc(NS(=O)(=O)c2ccc(cc2)-n2ncc3c2CC(C)(C)CC3=O)cc1 |
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| Structure | 
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