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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | RAC-beta serine/threonine-protein kinase | ||
| Ligand | BDBM50528416 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2120878 (CHEMBL4830025) | ||
| IC50 | 0.200000±n/a nM | ||
| Citation |  Che, J; Dai, X; Gao, J; Sheng, H; Zhan, W; Lu, Y; Li, D; Gao, Z; Jin, Z; Chen, B; Luo, P; Yang, B; Hu, Y; He, Q; Weng, Q; Dong, X Discovery of J Med Chem64:12163-12180 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| RAC-beta serine/threonine-protein kinase | |||
| Name: | RAC-beta serine/threonine-protein kinase | ||
| Synonyms: | AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 55766.64 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 481 | ||
| Sequence: |
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| BDBM50528416 | |||
| n/a | |||
| Name | BDBM50528416 | ||
| Synonyms: | CHEMBL4440965 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H23Cl2F2N5O3 | ||
| Mol. Mass. | 526.363 | ||
| SMILES | CNC(=O)C[C@@H]1C[C@H]([C@@H](CN1)NC(=O)c1cc(c(Cl)o1)-c1c(Cl)cnn1C)c1ccc(F)c(F)c1 |r,wU:8.11,5.4,wD:7.29,(76.34,-11.8,;75,-12.56,;73.67,-11.79,;73.68,-10.25,;72.34,-12.55,;71.01,-11.78,;71.01,-10.23,;69.68,-9.47,;68.34,-10.24,;68.34,-11.77,;69.67,-12.55,;67.01,-9.46,;65.68,-10.23,;65.67,-11.77,;64.34,-9.46,;62.93,-10.08,;61.9,-8.93,;62.68,-7.6,;62.05,-6.19,;64.18,-7.92,;60.37,-9.09,;59.59,-10.42,;60.22,-11.83,;58.09,-10.1,;57.93,-8.57,;59.34,-7.94,;59.66,-6.44,;69.68,-7.94,;68.35,-7.17,;68.35,-5.62,;69.68,-4.85,;69.67,-3.31,;71.01,-5.62,;72.34,-4.84,;71.02,-7.17,)| | ||
| Structure | 
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