| Reaction Details |
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 | Report a problem with these data |
| Target | Ribosomal protein S6 kinase beta-1 |
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| Ligand | BDBM50573869 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2120894 (CHEMBL4830041) |
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| IC50 | 229±n/a nM |
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| Citation |  Che, J; Dai, X; Gao, J; Sheng, H; Zhan, W; Lu, Y; Li, D; Gao, Z; Jin, Z; Chen, B; Luo, P; Yang, B; Hu, Y; He, Q; Weng, Q; Dong, X Discovery of J Med Chem64:12163-12180 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribosomal protein S6 kinase beta-1 |
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| Name: | Ribosomal protein S6 kinase beta-1 |
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| Synonyms: | 70 kDa ribosomal protein S6 kinase 1 | 70 kDa ribosomal protein S6 kinase 1 (P70s6k) | 70 kDa ribosomal protein kinase (p70S6K) | KS6B1_HUMAN | Protein kinase 70S6K (T412E) | RAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1 | RPS6KB1 | Ribosomal protein S6 kinase (P70S6K) | Ribosomal protein S6 kinase I | S6K1 | STK14A | p70 S6 ribosomal protein kinase 1 | p70S6K1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 59139.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | His-tagged S6K1. |
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| Residue: | 525 |
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| Sequence: | MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
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| BDBM50573869 |
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| n/a |
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| Name | BDBM50573869 |
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| Synonyms: | CHEMBL4556790 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22ClF3N4O |
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| Mol. Mass. | 450.884 |
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| SMILES | Cl.Cn1nccc1-c1ccc(C(=O)N[C@@H]2CNCC[C@H]2c2ccc(F)c(F)c2)c(F)c1 |r| |
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| Structure | 
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