Reaction Details |
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Target | Aurora kinase B/Inner centromere protein |
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Ligand | BDBM117012 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2122113 (CHEMBL4831260) |
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IC50 | 4.0±n/a nM |
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Citation | DeSelm, L; Huck, B; Lan, R; Neagu, C; Potnick, J; Xiao, Y; Chen, X; Jones, R; Richardson, TE; Heasley, BH; Haxell, T; Moore, J; Tian, H; Georgi, K; Rohdich, F; Sutton, A; Johnson, T; Mochalkin, I; Jackson, J; Lin, J; Crowley, L; Machl, A; Clark, A; Wilker, E; Sherer, B; Goutopoulos, A Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers. J Med Chem64:14603-14619 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase B/Inner centromere protein |
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Name: | Aurora kinase B/Inner centromere protein |
Synonyms: | Aurora B/Incenp |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Aurora kinase B |
Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
Type: | Protein |
Mol. Mass.: | 39327.72 |
Organism: | Homo sapiens (Human) |
Description: | Q96GD4 |
Residue: | 344 |
Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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Component 2 |
Name: | Inner centromere protein |
Synonyms: | INCENP | INCE_HUMAN |
Type: | Protein |
Mol. Mass.: | 105461.33 |
Organism: | Homo sapiens (Human) |
Description: | Q9NQS7 |
Residue: | 918 |
Sequence: | MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTP
SQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSV
LRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAE
QHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATP
QDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDS
QSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLE
RLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAAS
SPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPS
SPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQ
RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE
QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH
QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA
EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA
KEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRK
PIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSP
PLQGARVPSSLAYSLKKH
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BDBM117012 |
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n/a |
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Name | BDBM117012 |
Synonyms: | US8637532, 739 |
Type | Small organic molecule |
Emp. Form. | C18H18FN5O |
Mol. Mass. | 339.3668 |
SMILES | CNC[C@@H](Nc1ncnc2c(cccc12)C(N)=O)c1cccc(F)c1 |r| |
Structure |
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