Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM50524862 (CHEMBL4475680) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare Curated by ChEMBL | Assay Description Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b... | J Med Chem 62: 11119-11134 (2019) Article DOI: 10.1021/acs.jmedchem.9b01070 BindingDB Entry DOI: 10.7270/Q26H4MXQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM50524862 (CHEMBL4475680) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare Curated by ChEMBL | Assay Description Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b... | J Med Chem 62: 11119-11134 (2019) Article DOI: 10.1021/acs.jmedchem.9b01070 BindingDB Entry DOI: 10.7270/Q26H4MXQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM401307 (US10005756, Compound A78) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare Curated by ChEMBL | Assay Description Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b... | J Med Chem 62: 11119-11134 (2019) Article DOI: 10.1021/acs.jmedchem.9b01070 BindingDB Entry DOI: 10.7270/Q26H4MXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM401307 (US10005756, Compound A78) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare Curated by ChEMBL | Assay Description Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b... | J Med Chem 62: 11119-11134 (2019) Article DOI: 10.1021/acs.jmedchem.9b01070 BindingDB Entry DOI: 10.7270/Q26H4MXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM50531161 (CHEMBL4448724) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare Curated by ChEMBL | Assay Description Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b... | J Med Chem 62: 11119-11134 (2019) Article DOI: 10.1021/acs.jmedchem.9b01070 BindingDB Entry DOI: 10.7270/Q26H4MXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM50531161 (CHEMBL4448724) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare Curated by ChEMBL | Assay Description Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b... | J Med Chem 62: 11119-11134 (2019) Article DOI: 10.1021/acs.jmedchem.9b01070 BindingDB Entry DOI: 10.7270/Q26H4MXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM50531163 (CHEMBL4464946) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare Curated by ChEMBL | Assay Description Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b... | J Med Chem 62: 11119-11134 (2019) Article DOI: 10.1021/acs.jmedchem.9b01070 BindingDB Entry DOI: 10.7270/Q26H4MXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methionine aminopeptidase 2 (Homo sapiens (Human)) | BDBM50531163 (CHEMBL4464946) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare Curated by ChEMBL | Assay Description Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b... | J Med Chem 62: 11119-11134 (2019) Article DOI: 10.1021/acs.jmedchem.9b01070 BindingDB Entry DOI: 10.7270/Q26H4MXQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50505332 (CHEMBL4567515) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 6.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare KGaA Curated by ChEMBL | Assay Description Inhibition of human ERG expressed in HEK293 cells at -80 mV holding potential by whole cell patch clamp method | J Med Chem 62: 7897-7909 (2019) Article DOI: 10.1021/acs.jmedchem.9b00656 BindingDB Entry DOI: 10.7270/Q2FJ2M28 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50189412 (CHEMBL3827983) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24... | ACS Med Chem Lett 7: 573-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00022 BindingDB Entry DOI: 10.7270/Q2N87CRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50189417 (CHEMBL3828116) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24... | ACS Med Chem Lett 7: 573-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00022 BindingDB Entry DOI: 10.7270/Q2N87CRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM50505331 (CHEMBL4458129) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare KGaA Curated by ChEMBL | Assay Description Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ... | J Med Chem 62: 7897-7909 (2019) Article DOI: 10.1021/acs.jmedchem.9b00656 BindingDB Entry DOI: 10.7270/Q2FJ2M28 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM50593627 (CHEMBL5199558) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) from rat liver | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50191472 (CHEMBL3956719) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA Curated by ChEMBL | Assay Description Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ... | J Med Chem 59: 9337-9349 (2016) BindingDB Entry DOI: 10.7270/Q2K64M1C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50189435 (CHEMBL3828003) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24... | ACS Med Chem Lett 7: 573-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00022 BindingDB Entry DOI: 10.7270/Q2N87CRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM50505332 (CHEMBL4567515) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare KGaA Curated by ChEMBL | Assay Description Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ... | J Med Chem 62: 7897-7909 (2019) Article DOI: 10.1021/acs.jmedchem.9b00656 BindingDB Entry DOI: 10.7270/Q2FJ2M28 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C (Homo sapiens (Human)) | BDBM50189434 (CHEMBL3828221) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647... | ACS Med Chem Lett 7: 573-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00022 BindingDB Entry DOI: 10.7270/Q2N87CRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM50505331 (CHEMBL4458129) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare KGaA Curated by ChEMBL | Assay Description Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed... | J Med Chem 62: 7897-7909 (2019) Article DOI: 10.1021/acs.jmedchem.9b00656 BindingDB Entry DOI: 10.7270/Q2FJ2M28 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM50409634 (CHEMBL5274873) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium berghei | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM50409622 (CHEMBL5272750) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM50409634 (CHEMBL5274873) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C (Homo sapiens (Human)) | BDBM50189415 (CHEMBL3828637) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647... | ACS Med Chem Lett 7: 573-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00022 BindingDB Entry DOI: 10.7270/Q2N87CRB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM50593627 (CHEMBL5199558) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM50409619 (CHEMBL5271127) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM50409622 (CHEMBL5272750) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) from rat liver | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C (Homo sapiens (Human)) | BDBM50189428 (CHEMBL3828458) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647... | ACS Med Chem Lett 7: 573-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00022 BindingDB Entry DOI: 10.7270/Q2N87CRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM50409619 (CHEMBL5271127) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) from rat liver | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50189436 (CHEMBL3827327) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24... | ACS Med Chem Lett 7: 573-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00022 BindingDB Entry DOI: 10.7270/Q2N87CRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C (Homo sapiens (Human)) | BDBM50189447 (CHEMBL3828553) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647... | ACS Med Chem Lett 7: 573-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00022 BindingDB Entry DOI: 10.7270/Q2N87CRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM50409626 (CHEMBL5284314) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium berghei | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM50505324 (CHEMBL4588170) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare KGaA Curated by ChEMBL | Assay Description Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed... | J Med Chem 62: 7897-7909 (2019) Article DOI: 10.1021/acs.jmedchem.9b00656 BindingDB Entry DOI: 10.7270/Q2FJ2M28 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM50593627 (CHEMBL5199558) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proteasome subunit beta type-8 (Homo sapiens (Human)) | BDBM50069989 ((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00604 BindingDB Entry DOI: 10.7270/Q200064W | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM50505332 (CHEMBL4567515) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare KGaA Curated by ChEMBL | Assay Description Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed... | J Med Chem 62: 7897-7909 (2019) Article DOI: 10.1021/acs.jmedchem.9b00656 BindingDB Entry DOI: 10.7270/Q2FJ2M28 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C (Homo sapiens (Human)) | BDBM50191414 (CHEMBL3947140) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA Curated by ChEMBL | Assay Description Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat... | J Med Chem 59: 9337-9349 (2016) BindingDB Entry DOI: 10.7270/Q2K64M1C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM50505324 (CHEMBL4588170) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare KGaA Curated by ChEMBL | Assay Description Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ... | J Med Chem 62: 7897-7909 (2019) Article DOI: 10.1021/acs.jmedchem.9b00656 BindingDB Entry DOI: 10.7270/Q2FJ2M28 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C (Homo sapiens (Human)) | BDBM50191472 (CHEMBL3956719) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck KGaA Curated by ChEMBL | Assay Description Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat... | J Med Chem 59: 9337-9349 (2016) BindingDB Entry DOI: 10.7270/Q2K64M1C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM50593627 (CHEMBL5199558) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) of Plasmodium berghei | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM50505335 (CHEMBL4584689) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare KGaA Curated by ChEMBL | Assay Description Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed... | J Med Chem 62: 7897-7909 (2019) Article DOI: 10.1021/acs.jmedchem.9b00656 BindingDB Entry DOI: 10.7270/Q2FJ2M28 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-C (Homo sapiens (Human)) | BDBM50189417 (CHEMBL3828116) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647... | ACS Med Chem Lett 7: 573-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00022 BindingDB Entry DOI: 10.7270/Q2N87CRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM50409618 (CHEMBL5281076) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) from rat liver | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM50409632 (CHEMBL5279709) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM50505334 (CHEMBL4551200) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare KGaA Curated by ChEMBL | Assay Description Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS2 (873 to 1166 residues) expressed in baculovirus infected sf9 cells assessed ... | J Med Chem 62: 7897-7909 (2019) Article DOI: 10.1021/acs.jmedchem.9b00656 BindingDB Entry DOI: 10.7270/Q2FJ2M28 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50163767 (CHEMBL3798944) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assay | J Med Chem 59: 1078-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01685 BindingDB Entry DOI: 10.7270/Q29025P6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM50409623 (CHEMBL5280682) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) of Neisseria gonorrhoea | Citation and Details | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human)) | BDBM50505334 (CHEMBL4551200) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Healthcare KGaA Curated by ChEMBL | Assay Description Inhibition of GST tagged-TEV cleavage site-fused human recombinant TNKS1 (1023 to 1327 residues) expressed in baculovirus infected sf9 cells assessed... | J Med Chem 62: 7897-7909 (2019) Article DOI: 10.1021/acs.jmedchem.9b00656 BindingDB Entry DOI: 10.7270/Q2FJ2M28 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50163774 (CHEMBL3797855) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lanthascreen binding assay | J Med Chem 59: 1078-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01685 BindingDB Entry DOI: 10.7270/Q29025P6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50189415 (CHEMBL3828637) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24... | ACS Med Chem Lett 7: 573-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00022 BindingDB Entry DOI: 10.7270/Q2N87CRB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Proteasome subunit beta type-8 (Homo sapiens (Human)) | BDBM50601642 (CHEMBL5188533) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00604 BindingDB Entry DOI: 10.7270/Q200064W | ||||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human)) | BDBM50409621 (CHEMBL5269584) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibitory activity against dihydrofolate reductase (DHFR) from rat liver | Citation and Details | |||||||||||
More data for this Ligand-Target Pair |
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