| Reaction Details |
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 | Report a problem with these data |
| Target | Phenylalanine--tRNA ligase, mitochondrial |
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| Ligand | BDBM50140713 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_154873 (CHEMBL768847) |
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| IC50 | >100000±n/a nM |
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| Citation |  Yu, XY; Finn, J; Hill, JM; Wang, ZG; Keith, D; Silverman, J; Oliver, N A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases. Bioorg Med Chem Lett14:1339-42 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phenylalanine--tRNA ligase, mitochondrial |
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| Name: | Phenylalanine--tRNA ligase, mitochondrial |
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| Synonyms: | FARS1 | FARS2 | PheRS | Phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase mitochondrial | Phenylalanyl-tRNA synthetase, mitochondrial | SYFM_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52367.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_154870 |
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| Residue: | 451 |
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| Sequence: | MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQ
DDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVV
TTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRR
DQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVE
FDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVN
SAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKY
PAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRH
MERTLSQREVRHIHQALQEAAVQLLGVEGRF
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| BDBM50140713 |
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| n/a |
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| Name | BDBM50140713 |
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| Synonyms: | 4-benzoyl-2-(3,4-dichlorophenyl)-6-phenyl-(3aR,6R,6aS)-perhydropyrrolo[3,4-c]pyrrole-1,3-dione | CHEMBL283594 | CHEMBL435161 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H18Cl2N2O3 |
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| Mol. Mass. | 465.328 |
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| SMILES | Oc1c2C(NC(c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)c1ccccc1 |
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| Structure | 
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