Reaction Details |
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Target | Phenylalanine--tRNA ligase, mitochondrial |
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Ligand | BDBM50140727 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_154871 (CHEMBL768845) |
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IC50 | 5000±n/a nM |
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Citation | Yu, XY; Finn, J; Hill, JM; Wang, ZG; Keith, D; Silverman, J; Oliver, N A series of heterocyclic inhibitors of phenylalanyl-tRNA synthetases with antibacterial activity. Bioorg Med Chem Lett14:1343-6 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Phenylalanine--tRNA ligase, mitochondrial |
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Name: | Phenylalanine--tRNA ligase, mitochondrial |
Synonyms: | FARS1 | FARS2 | PheRS | Phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase mitochondrial | Phenylalanyl-tRNA synthetase, mitochondrial | SYFM_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 52367.99 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_154870 |
Residue: | 451 |
Sequence: | MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQ
DDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVV
TTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRR
DQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVE
FDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVN
SAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKY
PAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRH
MERTLSQREVRHIHQALQEAAVQLLGVEGRF
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BDBM50140727 |
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n/a |
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Name | BDBM50140727 |
Synonyms: | 5-(3,4-dichlorophenyl)-3-phenyl-(3R,3aR,6aS)-spiro[perhydrofuro[3,4-c]pyrrole-1,2'-(2',3'-dihydro-1'H-indene)]-1',3',4,6-tetraone | CHEMBL27258 |
Type | Small organic molecule |
Emp. Form. | C26H15Cl2NO5 |
Mol. Mass. | 492.307 |
SMILES | Oc1c2[C@@H](OC3(C(=O)c4ccccc4C3=O)c2c(O)n1-c1ccc(Cl)c(Cl)c1)c1ccccc1 |
Structure |
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