| Reaction Details |
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 | Report a problem with these data |
| Target | Phenylalanine--tRNA ligase, mitochondrial |
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| Ligand | BDBM50140729 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_154871 (CHEMBL768845) |
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| IC50 | 510±n/a nM |
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| Citation |  Yu, XY; Finn, J; Hill, JM; Wang, ZG; Keith, D; Silverman, J; Oliver, N A series of heterocyclic inhibitors of phenylalanyl-tRNA synthetases with antibacterial activity. Bioorg Med Chem Lett14:1343-6 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phenylalanine--tRNA ligase, mitochondrial |
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| Name: | Phenylalanine--tRNA ligase, mitochondrial |
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| Synonyms: | FARS1 | FARS2 | PheRS | Phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase mitochondrial | Phenylalanyl-tRNA synthetase, mitochondrial | SYFM_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52367.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_154870 |
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| Residue: | 451 |
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| Sequence: | MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQ
DDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVV
TTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRR
DQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVE
FDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVN
SAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKY
PAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRH
MERTLSQREVRHIHQALQEAAVQLLGVEGRF
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| BDBM50140729 |
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| n/a |
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| Name | BDBM50140729 |
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| Synonyms: | 13N-(3,4-dichlorophenyl)-2-hydroxy-11-oxo-14-phenyl-(1S,2R,9S,12S,13R,14R)-10,15-dioxatetracyclo[7.6.0.01,12.03,8]pentadeca-3(8),4,6-triene-13-carboxamide | CHEMBL284654 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H19Cl2NO5 |
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| Mol. Mass. | 496.339 |
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| SMILES | O[C@@H]1c2ccccc2[C@@H]2OC(=O)[C@H]3[C@H]([C@@H](O[C@@]123)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1 |
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| Structure | 
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