Reaction Details |
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Target | Phenylalanine--tRNA ligase, mitochondrial |
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Ligand | BDBM50140730 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_154870 (CHEMBL768844) |
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IC50 | 11000±n/a nM |
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Citation | Yu, XY; Finn, J; Hill, JM; Wang, ZG; Keith, D; Silverman, J; Oliver, N A series of heterocyclic inhibitors of phenylalanyl-tRNA synthetases with antibacterial activity. Bioorg Med Chem Lett14:1343-6 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Phenylalanine--tRNA ligase, mitochondrial |
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Name: | Phenylalanine--tRNA ligase, mitochondrial |
Synonyms: | FARS1 | FARS2 | PheRS | Phenylalanine--tRNA ligase | Phenylalanyl-tRNA synthetase mitochondrial | Phenylalanyl-tRNA synthetase, mitochondrial | SYFM_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 52367.99 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_154870 |
Residue: | 451 |
Sequence: | MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQ
DDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVV
TTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRR
DQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVE
FDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVN
SAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKY
PAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRH
MERTLSQREVRHIHQALQEAAVQLLGVEGRF
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BDBM50140730 |
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n/a |
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Name | BDBM50140730 |
Synonyms: | 4-(3,4-dichlorophenylcarbamoyl)-1',3'-dioxo-5-phenylspiro[tetrahydrofuran-2,2'-(2',3'-dihydro-1'H-indene)]-3-carboxylic acid | CHEMBL29865 |
Type | Small organic molecule |
Emp. Form. | C26H17Cl2NO6 |
Mol. Mass. | 510.322 |
SMILES | OC(=O)[C@@H]1[C@@H]([C@@H](OC11C(=O)c2ccccc2C1=O)c1ccccc1)C(=O)Nc1ccc(Cl)c(Cl)c1 |
Structure |
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