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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Proto-oncogene tyrosine-protein kinase receptor Ret | ||
| Ligand | BDBM50575345 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2125062 (CHEMBL4834295) | ||
| IC50 | 5.0±n/a nM | ||
| Citation |  Mathison, CJN; Yang, Y; Nelson, J; Huang, Z; Jiang, J; Chianelli, D; Rucker, PV; Roland, J; Xie, YF; Epple, R; Bursulaya, B; Lee, C; Gao, MY; Shaffer, J; Briones, S; Sarkisova, Y; Galkin, A; Li, L; Li, N; Li, C; Hua, S; Kasibhatla, S; Kinyamu-Akunda, J; Kikkawa, R; Molteni, V; Tellew, JE Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3- ACS Med Chem Lett12:1912-1919 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Proto-oncogene tyrosine-protein kinase receptor Ret | |||
| Name: | Proto-oncogene tyrosine-protein kinase receptor Ret | ||
| Synonyms: | CDHF12 | CDHR16 | Cadherin family member 12 | PTC | Proto-oncogene c-Ret | RET | RET51 | RET_HUMAN | Tyrosine-protein kinase Ret (RET) | ||
| Type: | Protein | ||
| Mol. Mass.: | 124318.29 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P07949 | ||
| Residue: | 1114 | ||
| Sequence: |
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| BDBM50575345 | |||
| n/a | |||
| Name | BDBM50575345 | ||
| Synonyms: | CHEMBL4848347 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H26N6O2 | ||
| Mol. Mass. | 406.4808 | ||
| SMILES | CC(=O)N1CCN(CC1)[C@H]1C[C@H](C1)n1cc(-c2cccc(O)c2)c2c(N)ncnc12 |r,wU:11.14,9.9,(15.86,-22.2,;17.36,-21.88,;18.39,-23.03,;17.84,-20.42,;16.81,-19.27,;17.28,-17.81,;18.79,-17.49,;19.83,-18.62,;19.35,-20.09,;19.26,-16.03,;18.55,-14.66,;19.92,-13.95,;20.63,-15.32,;20.39,-12.48,;19.48,-11.24,;20.38,-9.99,;19.9,-8.53,;18.4,-8.22,;17.91,-6.76,;18.94,-5.61,;20.45,-5.92,;21.48,-4.77,;20.93,-7.38,;21.85,-10.46,;23.18,-9.68,;23.18,-8.14,;24.52,-10.45,;24.52,-12,;23.19,-12.77,;21.85,-12,)| | ||
| Structure | 
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