Reaction Details |
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Target | Leukotriene A-4 hydrolase |
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Ligand | BDBM50575468 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2125316 (CHEMBL4834661) |
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IC50 | 129±n/a nM |
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Citation | Markert, C; Thoma, G; Srinivas, H; Bollbuck, B; Lüönd, RM; Miltz, W; Wälchli, R; Wolf, R; Hinrichs, J; Bergsdorf, C; Azzaoui, K; Penno, CA; Klein, K; Wack, N; Jäger, P; Hasler, F; Beerli, C; Loetscher, P; Dawson, J; Wieczorek, G; Numao, S; Littlewood-Evans, A; Röhn, TA Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A J Med Chem64:1889-1903 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Leukotriene A-4 hydrolase |
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Name: | Leukotriene A-4 hydrolase |
Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
Type: | Hydrolase; metalloprotease |
Mol. Mass.: | 69280.41 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant LTA4H. |
Residue: | 611 |
Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
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BDBM50575468 |
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n/a |
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Name | BDBM50575468 |
Synonyms: | CHEMBL4879150 |
Type | Small organic molecule |
Emp. Form. | C15H14ClN5O |
Mol. Mass. | 315.758 |
SMILES | NCCn1nnc(n1)-c1ccc(Oc2ccc(Cl)cc2)cc1 |
Structure |
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