| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50142743 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_90868 |
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| IC50 | 22000±n/a nM |
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| Citation |  Costi, R; Di Santo, R; Artico, M; Roux, A; Ragno, R; Massa, S; Tramontano, E; La Colla, M; Loddo, R; Marongiu, ME; Pani, A; La Colla, P 6-aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays. Bioorg Med Chem Lett14:1745-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | Human immunodeficiency virus type 1 integrase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32231.48 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_90865 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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| BDBM50142743 |
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| n/a |
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| Name | BDBM50142743 |
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| Synonyms: | (E)-6-[1-(4-Methoxy-benzyl)-1H-pyrrol-2-yl]-2,4-dioxo-hex-5-enoic acid | CHEMBL198366 | CHEMBL46032 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17NO5 |
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| Mol. Mass. | 327.3313 |
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| SMILES | COc1ccc(Cn2cccc2C=CC(=O)CC(=O)C(O)=O)cc1 |w:13.14| |
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| Structure | 
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