| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Integrase |
|---|
| Ligand | BDBM50142738 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_90868 (CHEMBL699301) |
|---|
| IC50 | 50000±n/a nM |
|---|
| Citation |  Costi, R; Di Santo, R; Artico, M; Roux, A; Ragno, R; Massa, S; Tramontano, E; La Colla, M; Loddo, R; Marongiu, ME; Pani, A; La Colla, P 6-aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays. Bioorg Med Chem Lett14:1745-9 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Integrase |
|---|
| Name: | Integrase |
|---|
| Synonyms: | Human immunodeficiency virus type 1 integrase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 32231.48 |
|---|
| Organism: | Human immunodeficiency virus 1 |
|---|
| Description: | ChEMBL_90865 |
|---|
| Residue: | 288 |
|---|
| Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
|
|
|
|---|
| BDBM50142738 |
|---|
| n/a |
|---|
| Name | BDBM50142738 |
|---|
| Synonyms: | (E)-6-[1-(4-Chloro-benzyl)-1H-pyrrol-2-yl]-2,4-dioxo-hex-5-enoic acid ethyl ester | CHEMBL417356 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H18ClNO4 |
|---|
| Mol. Mass. | 359.804 |
|---|
| SMILES | CCOC(=O)C(=O)CC(=O)C=Cc1cccn1Cc1ccc(Cl)cc1 |w:10.9| |
|---|
| Structure | 
|
|---|
Search and Browse
