Reaction Details |
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Target | Kynurenine 3-monooxygenase |
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Ligand | BDBM50576351 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2127057 (CHEMBL4836402) |
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IC50 | 29±n/a nM |
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Citation | Tsuboi, K; Kimura, H; Nakatsuji, Y; Kassai, M; Deai, Y; Isobe, Y Discovery of N-(6-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridazin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)methanesulfonamide as a brain-permeable and metabolically stable kynurenine monooxygenase inhibitor. Bioorg Med Chem Lett44:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Kynurenine 3-monooxygenase |
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Name: | Kynurenine 3-monooxygenase |
Synonyms: | KMO | KMO_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 55831.03 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1487479 |
Residue: | 486 |
Sequence: | MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSH
RGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLT
AAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKK
PRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMP
FEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCV
LLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLS
MYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKK
VINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQI
SNLISR
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BDBM50576351 |
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n/a |
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Name | BDBM50576351 |
Synonyms: | CHEMBL4866526 |
Type | Small organic molecule |
Emp. Form. | C21H27FN4O2S |
Mol. Mass. | 418.528 |
SMILES | Fc1ccc(-c2ccc(NS(=O)(=O)CC3CCCC3)nn2)c(c1)N1CCCCC1 |
Structure |
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