| Reaction Details |
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 | Report a problem with these data |
| Target | Catenin beta-1 |
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| Ligand | BDBM50577925 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2131492 (CHEMBL4841007) |
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| IC50 | 11000±n/a nM |
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| Citation |  Wang, Z; Zhang, M; Quereda, V; Frydman, SM; Ming, Q; Luca, VC; Duckett, DR; Ji, H Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the ?-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction. J Med Chem64:12109-12131 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Catenin beta-1 |
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| Name: | Catenin beta-1 |
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| Synonyms: | CTNB1_HUMAN | CTNNB | CTNNB1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 85484.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1504364 |
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| Residue: | 781 |
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| Sequence: | MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS
QVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPT
NVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSK
KEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL
VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC
LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEA
GGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA
AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM
AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL
VRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFV
QLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF
RMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFH
SGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD
L
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| BDBM50577925 |
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| n/a |
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| Name | BDBM50577925 |
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| Synonyms: | CHEMBL4846565 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H43ClN6O3 |
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| Mol. Mass. | 607.186 |
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| SMILES | Cl.CC(C)(Oc1cccc(c1)N1CCC[C@H](C1)C(=O)N(Cc1ccc(cc1)-c1cn[nH]c1)C1CC1)C(=O)N1CCNCC1 |r| |
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| Structure | 
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