| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
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| Ligand | BDBM50580117 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2147064 (CHEMBL5031410) |
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| IC50 | 190±n/a nM |
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| Citation |  Lee, LC; Peng, YH; Chang, HH; Hsu, T; Lu, CT; Huang, CH; Hsueh, CC; Kung, FC; Kuo, CC; Jiaang, WT; Wu, SY Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2). J Med Chem64:11288-11301 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
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| Name: | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
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| Synonyms: | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | MTDC_HUMAN | MTHFD2 | Methenyltetrahydrofolate cyclohydrolase | NAD-dependent methylenetetrahydrofolate dehydrogenase | NMDMC |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37904.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109900 |
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| Residue: | 350 |
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| Sequence: | MAATSLMSALAARLLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEVEEW
VASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKL
NNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGV
WEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQL
KKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQ
KAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREVLKSKELGVATN
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| BDBM50580117 |
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| n/a |
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| Name | BDBM50580117 |
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| Synonyms: | CHEMBL5076176 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H26ClN7O7 |
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| Mol. Mass. | 608.002 |
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| SMILES | Cn1c(Nc2ccc(cc2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)nc2n(C)c(=O)n(Cc3cc4c(Cl)cccc4[nH]3)c(=O)c12 |r| |
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| Structure | 
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