| Reaction Details |
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 | Report a problem with these data |
| Target | C-1-tetrahydrofolate synthase, cytoplasmic |
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| Ligand | BDBM50580113 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2147065 (CHEMBL5031411) |
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| IC50 | >10000±n/a nM |
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| Citation |  Lee, LC; Peng, YH; Chang, HH; Hsu, T; Lu, CT; Huang, CH; Hsueh, CC; Kung, FC; Kuo, CC; Jiaang, WT; Wu, SY Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2). J Med Chem64:11288-11301 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-1-tetrahydrofolate synthase, cytoplasmic |
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| Name: | C-1-tetrahydrofolate synthase, cytoplasmic |
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| Synonyms: | 1.5.1.5 | 3.5.4.9 | 6.3.4.3 | C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed | C1-THF synthase | C1TC_HUMAN | Epididymis secretory sperm binding protein | Formyltetrahydrofolate synthetase | MTHFC | MTHFD | MTHFD1 | Methenyltetrahydrofolate cyclohydrolase | Methylenetetrahydrofolate dehydrogenase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 101538.58 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_11303 |
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| Residue: | 935 |
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| Sequence: | MAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAA
EEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAP
EKDVDGLTSINAGKLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAP
MHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINY
VPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKP
GKWMIQYNNLNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSAL
ERLKHRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGI
KGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLV
PSVNGVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRF
LRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPV
SAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVG
PEGFVVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLP
KAYIQENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAF
DAVKCTHWAEGGKGALALAQAVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIE
LLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFL
YPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
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| BDBM50580113 |
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| n/a |
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| Name | BDBM50580113 |
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| Synonyms: | CHEMBL5090659 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23ClN8O4 |
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| Mol. Mass. | 522.944 |
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| SMILES | Cc1cc(Nc2nc3n(C)c(=O)n(Cc4cc5c(Cl)cccc5[nH]4)c(=O)c3n2C)nc(CCC(O)=O)n1 |
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| Structure | 
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