| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-1-tetrahydrofolate synthase, cytoplasmic |
|---|
| Ligand | BDBM50580120 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2147065 (CHEMBL5031411) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Lee, LC; Peng, YH; Chang, HH; Hsu, T; Lu, CT; Huang, CH; Hsueh, CC; Kung, FC; Kuo, CC; Jiaang, WT; Wu, SY Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2). J Med Chem64:11288-11301 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-1-tetrahydrofolate synthase, cytoplasmic |
|---|
| Name: | C-1-tetrahydrofolate synthase, cytoplasmic |
|---|
| Synonyms: | 1.5.1.5 | 3.5.4.9 | 6.3.4.3 | C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed | C1-THF synthase | C1TC_HUMAN | Epididymis secretory sperm binding protein | Formyltetrahydrofolate synthetase | MTHFC | MTHFD | MTHFD1 | Methenyltetrahydrofolate cyclohydrolase | Methylenetetrahydrofolate dehydrogenase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 101538.58 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_11303 |
|---|
| Residue: | 935 |
|---|
| Sequence: | MAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAA
EEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAP
EKDVDGLTSINAGKLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAP
MHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINY
VPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKP
GKWMIQYNNLNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSAL
ERLKHRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGI
KGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLV
PSVNGVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRF
LRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPV
SAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVG
PEGFVVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLP
KAYIQENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAF
DAVKCTHWAEGGKGALALAQAVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIE
LLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFL
YPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
|
|
|
|---|
| BDBM50580120 |
|---|
| n/a |
|---|
| Name | BDBM50580120 |
|---|
| Synonyms: | CHEMBL5077920 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H16Cl2N4O5 |
|---|
| Mol. Mass. | 463.271 |
|---|
| SMILES | Cn1c(NC(=O)Nc2ccc(cc2)C(O)=O)cc(=O)n(Cc2ccc(Cl)c(Cl)c2)c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
