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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Ligand | BDBM50581223 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2150101 (CHEMBL5034563) | ||
| Ki | 1500±n/a nM | ||
| Citation |  Lee Walmsley, D; Murray, JB; Dokurno, P; Massey, AJ; Benwell, K; Fiumana, A; Foloppe, N; Ray, S; Smith, J; Surgenor, AE; Edmonds, T; Demarles, D; Burbridge, M; Cruzalegui, F; Kotschy, A; Hubbard, RE Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J Med Chem64:8971-8991 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | |||
| Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||
| Synonyms: | DYR1A_HUMAN | DYRK | DYRK1A | Dual specificity YAK1-related kinase | Dual specificity YAK1-related kinase 1A (Dyrk1A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Dual-specificity tyrosine-regulated kinases 1A | HP86 | MNB | MNBH | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 85616.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13627 | ||
| Residue: | 763 | ||
| Sequence: |
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| BDBM50581223 | |||
| n/a | |||
| Name | BDBM50581223 | ||
| Synonyms: | CHEMBL5077073 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H17N5O | ||
| Mol. Mass. | 307.3498 | ||
| SMILES | COc1cccc(-c2c(C#N)c3c(N)nc(C)nc3n2C)c1C |(75.98,-11.92,;74.44,-11.92,;73.67,-13.25,;72.13,-13.25,;71.36,-14.59,;72.14,-15.92,;73.67,-15.92,;74.44,-17.25,;73.81,-18.66,;72.3,-18.98,;70.79,-19.3,;74.96,-19.69,;74.96,-21.23,;73.62,-22.01,;76.3,-22.01,;77.64,-21.23,;78.97,-22,;77.64,-19.69,;76.3,-18.92,;75.98,-17.41,;77.01,-16.26,;74.44,-14.58,;75.98,-14.58,)| | ||
| Structure | 
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