Reaction Details |
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Target | ATP-sensitive inward rectifier potassium channel 1 |
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Ligand | BDBM50582618 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2155247 (CHEMBL5039907) |
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IC50 | 45±n/a nM |
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Citation | Jiang, J; Ding, FX; Zhou, X; Bateman, TJ; Dong, S; Gu, X; Keh deJesus, R; Pio, B; Tang, H; Chobanian, HR; Levorse, D; Hu, M; Thomas-Fowlkes, B; Margulis, M; Koehler, M; Weinglass, A; Gibson, J; Houle, K; Yudkovitz, J; Hampton, C; Pai, LY; Samuel, K; Cutarelli, T; Sullivan, K; Parmee, ER; Davies, I; Pasternak, A Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic. J Med Chem64:7691-7701 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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ATP-sensitive inward rectifier potassium channel 1 |
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Name: | ATP-sensitive inward rectifier potassium channel 1 |
Synonyms: | ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 44809.08 |
Organism: | Homo sapiens (Human) |
Description: | gi_223460826 |
Residue: | 391 |
Sequence: | MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM
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BDBM50582618 |
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n/a |
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Name | BDBM50582618 |
Synonyms: | CHEMBL5091929 |
Type | Small organic molecule |
Emp. Form. | C23H26N2O6 |
Mol. Mass. | 426.4623 |
SMILES | Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CN(C(=O)C2)C2=CC(=O)OC2)CC1 |r,t:26| |
Structure |
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