Reaction Details |
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Target | Serine/threonine-protein kinase 4 |
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Ligand | BDBM50583980 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2158669 (CHEMBL5043419) |
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IC50 | 80±n/a nM |
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Citation | Bata, N; Chaikuad, A; Bakas, NA; Limpert, AS; Lambert, LJ; Sheffler, DJ; Berger, LM; Liu, G; Yuan, C; Wang, L; Peng, Y; Dong, J; Celeridad, M; Layng, F; Knapp, S; Cosford, NDP Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia. J Med Chem65:1352-1369 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase 4 |
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Name: | Serine/threonine-protein kinase 4 |
Synonyms: | KRS2 | MST1 | STK4 | STK4_HUMAN | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase 4 (STK4) | Serine/threonine-protein kinase MST1 |
Type: | Enzyme |
Mol. Mass.: | 55611.40 |
Organism: | Homo sapiens (Human) |
Description: | Q13043 |
Residue: | 487 |
Sequence: | METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQ
VPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT
LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK
RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNP
PPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDV
KLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDT
LPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLK
NSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK
KRRQQNF
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BDBM50583980 |
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n/a |
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Name | BDBM50583980 |
Synonyms: | CHEMBL5089132 |
Type | Small organic molecule |
Emp. Form. | C17H17ClN4O |
Mol. Mass. | 328.796 |
SMILES | OC1CCN(CC1)c1ncnc2[nH]cc(-c3cccc(Cl)c3)c12 |
Structure |
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