| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase BTK |
|---|
| Ligand | BDBM195875 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2160715 (CHEMBL5045465) |
|---|
| IC50 | 1.2±n/a nM |
|---|
| Citation |  Dou, D; Diao, Y; Sha, W; Su, R; Tong, L; Li, W; Leng, L; Xie, L; Yu, Z; Song, H; Shen, Z; Zhu, L; Zhao, Z; Xie, H; Chen, Z; Li, H; Xu, Y Discovery of Pteridine-7(8 J Med Chem65:2694-2709 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase BTK |
|---|
| Name: | Tyrosine-protein kinase BTK |
|---|
| Synonyms: | AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 76289.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q06187 |
|---|
| Residue: | 659 |
|---|
| Sequence: | MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
|
|
|
|---|
| BDBM195875 |
|---|
| n/a |
|---|
| Name | BDBM195875 |
|---|
| Synonyms: | US9670213, Compound 020 N-(3-(2-(4-(4-methyl-1-piperazinyl)-phenylamino)-7-oxo-8(7H)-pteridin-yl)phenyl) acrylamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H26N8O2 |
|---|
| Mol. Mass. | 482.537 |
|---|
| SMILES | CN1CCN(CC1)c1ccc(Nc2ncc3ncc(=O)n(-c4cccc(NC(=O)C=C)c4)c3n2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
