| Reaction Details |
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 | Report a problem with these data |
| Target | Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
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| Ligand | BDBM50153769 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_310145 (CHEMBL838124) |
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| EC50 | 21±n/a nM |
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| Citation |  Li, Q; Claiborne, A; Li, T; Hasvold, L; Stoll, VS; Muchmore, S; Jakob, CG; Gu, W; Cohen, J; Hutchins, C; Frost, D; Rosenberg, SH; Sham, HL Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors. Bioorg Med Chem Lett14:5367-70 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
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| Name: | Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
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| Synonyms: | Protein farnesyltransferase | Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 38702 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
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| Synonyms: | CAAX farnesyltransferase subunit alpha | FNTA_MOUSE | FTase-alpha | Fnta | GGTase-I-alpha | Geranylgeranyl transferase type 1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Ras proteins prenyltransferase subunit alpha | Type I protein geranyl-geranyltransferase subunit alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43994.09 |
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| Organism: | Mus musculus |
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| Description: | EBI_10570 |
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| Residue: | 377 |
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| Sequence: | MAATEGVGESAAGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDS
PTYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLT
RDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYITAIIEEQPKNYQVWHHRRVLVEWLK
DPSQELEFIADILSQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQR
HFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLL
DLQPSHSSPYLIAFLVDVYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIG
RSLQSKHCRESDIPASV
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| Component 2 |
| Name: | Protein farnesyltransferase subunit beta |
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| Synonyms: | FNTB_MOUSE | Fntb | Protein farnesyltransferase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48811.61 |
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| Organism: | Mus musculus |
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| Description: | EBI_12341 |
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| Residue: | 437 |
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| Sequence: | MASSSSFTYYCPPSSSPVWSEPLYSLRPEHVRERLQDDSVETVTSIEQAKVEEKIQEVFS
SYKFNHLVPRLILQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
IVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQY
LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
GVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF
YHTCYCLSGLSIAQHFGSGAMLHDMVMGVPENVLQPTHPVYNIGPEKVIQATTHFLQKPV
PGFEECEDEVTSDPATD
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| BDBM50153769 |
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| n/a |
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| Name | BDBM50153769 |
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| Synonyms: | 5-(3-Chloro-phenyl)-6-({[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | CHEMBL187374 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H21ClN6O |
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| Mol. Mass. | 468.938 |
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| SMILES | Cn1c(CNCc2cncn2Cc2ccc(cc2)C#N)c(cc(C#N)c1=O)-c1cccc(Cl)c1 |
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| Structure | 
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