| Reaction Details |
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 | Report a problem with these data |
| Target | Pantetheinase |
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| Ligand | BDBM480931 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2162817 (CHEMBL5047678) |
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| IC50 | 0.560000±n/a nM |
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| Citation |  Casimiro-Garcia, A; Allais, C; Brennan, A; Choi, C; Dower, G; Farley, KA; Fleming, M; Flick, A; Frisbie, RK; Hall, J; Hepworth, D; Jones, H; Knafels, JD; Kortum, S; Lovering, FE; Mathias, JP; Mohan, S; Morgan, PM; Parng, C; Parris, K; Pullen, N; Schlerman, F; Stansfield, J; Strohbach, JW; Vajdos, FF; Vincent, F; Wang, H; Wang, X; Webster, R; Wright, SW Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1. J Med Chem65:757-784 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pantetheinase |
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| Name: | Pantetheinase |
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| Synonyms: | 3.5.1.92 | Pantetheine hydrolase | VNN1_MOUSE | Vanin-1 | Vascular non-inflammatory molecule 1 | Vnn1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57084.66 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_120311 |
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| Residue: | 512 |
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| Sequence: | MGMSWWLACAAAFSALCVLKASSLDTFLAAVYEHAVILPKDTLLPVSHSEALALMNQNLD
LLEGAIVSAAKQGAHIIVTPEDGIYGVRFTRDTIYPYLEEIPDPQVNWIPCDNPKRFGST
PVQERLSCLAKNNSIYVVANMGDKKPCNTSDSHCPPDGRFQYNTDVVFDSQGKLVARYHK
QNIFMGEDQFNVPMEPEFVTFDTPFGKFGVFTCFDILFHDPAVTLVTEFQVDTILFPTAW
MDVLPHLAAIEFHSAWAMGMGVNFLAANLHNPSRRMTGSGIYAPDSPRVFHYDRKTQEGK
LLFAQLKSHPIHSPVNWTSYASSVESTPTKTQEFQSIVFFDEFTFVELKGIKGNYTVCQN
DLCCHLSYQMSEKRADEVYAFGAFDGLHTVEGQYYLQICILLKCKTTNLRTCGSSVDTAF
TRFEMFSLSGTFGTRYVFPEVLLSEVKLAPGEFQVSSDGRLVSLKPTSGPVLTIGLFGRL
YGKDWASNASSDFIAHSLIIMLIVTPIIHYLC
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| BDBM480931 |
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| n/a |
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| Name | BDBM480931 |
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| Synonyms: | 8-oxa-2-azaspiro[4.5]dec-2-yl(2-{[(1S)-1-(pyrazin-2-yl)ethyl]amino}pyrimidin-5-yl)methanone | US10906888, Example 145 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H24N6O2 |
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| Mol. Mass. | 368.4329 |
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| SMILES | C[C@H](Nc1ncc(cn1)C(=O)N1CCC2(C1)CCOCC2)c1cnccn1 |r| |
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| Structure | 
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