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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone-lysine N-methyltransferase EZH2 | ||
| Ligand | BDBM50586163 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2165239 (CHEMBL5050100) | ||
| IC50 | 489±n/a nM | ||
| Citation |  Liang, R; Tomita, D; Sasaki, Y; Ginn, J; Michino, M; Huggins, DJ; Baxt, L; Kargman, S; Shahid, M; Aso, K; Duggan, M; Stamford, AW; DeStanchina, E; Liverton, N; Meinke, PT; Foley, MA; Phillips, RE A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors. ACS Med Chem Lett13:377-387 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone-lysine N-methyltransferase EZH2 | |||
| Name: | Histone-lysine N-methyltransferase EZH2 | ||
| Synonyms: | ENX-1 | EZH2 | EZH2_HUMAN | Enhancer of zeste homolog 2 (EZH2) | Histone-lysine N-methyltransferase EZH2 | KMT6 | Lysine N-methyltransferase 6 | ||
| Type: | Protein | ||
| Mol. Mass.: | 85367.84 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15910 | ||
| Residue: | 746 | ||
| Sequence: |
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| BDBM50586163 | |||
| n/a | |||
| Name | BDBM50586163 | ||
| Synonyms: | CHEMBL5094306 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H27ClN4O4 | ||
| Mol. Mass. | 470.949 | ||
| SMILES | CCN1CCN(Cc2c(OC)cc(C)[nH]c2=O)C(=O)c2c(Cl)c(ccc12)-c1c(C)noc1C |(.24,-4.48,;-.85,-3.39,;-.45,-1.9,;1.05,-1.54,;1.72,-.17,;1.05,1.21,;2.14,2.3,;3.62,1.9,;4.02,.41,;2.93,-.68,;3.33,-2.17,;5.51,.01,;6.6,1.1,;8.09,.7,;6.2,2.59,;4.71,2.99,;4.31,4.48,;-.46,1.55,;-.85,3.04,;-1.65,.6,;-2.98,1.37,;-2.98,2.91,;-4.32,.6,;-4.32,-.95,;-2.98,-1.71,;-1.65,-.94,;-5.65,1.37,;-7.06,.74,;-7.45,-.74,;-8.09,1.89,;-7.32,3.22,;-5.81,2.9,;-4.72,3.99,)| | ||
| Structure | 
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