| Reaction Details |
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 | Report a problem with these data |
| Target | Telomerase reverse transcriptase |
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| Ligand | BDBM50155659 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304144 (CHEMBL840260) |
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| EC50 | 5200±n/a nM |
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| Citation |  Harrison, RJ; Reszka, AP; Haider, SM; Romagnoli, B; Morrell, J; Read, MA; Gowan, SM; Incles, CM; Kelland, LR; Neidle, S Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. Bioorg Med Chem Lett14:5845-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Telomerase reverse transcriptase |
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| Name: | Telomerase reverse transcriptase |
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| Synonyms: | EST2 | TCS1 | TERT | TERT_HUMAN | TRT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 127099.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1447029 |
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| Residue: | 1132 |
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| Sequence: | MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPW
DARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVR
SYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGA
ATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRR
GAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVG
RQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRL
VETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVT
PAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGS
RHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEI
LAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRE
LSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKA
LFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTI
PQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHL
QETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTL
LCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNL
RKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTF
NRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLP
FHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLL
KLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
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| BDBM50155659 |
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| n/a |
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| Name | BDBM50155659 |
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| Synonyms: | 3,6-Di-pyrrolidin-1-yl-acridine | CHEMBL186037 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23N3 |
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| Mol. Mass. | 317.4274 |
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| SMILES | C1CCN(C1)c1ccc2cc3ccc(cc3nc2c1)N1CCCC1 |
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| Structure | 
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